1. Hepatology 2000; 31: 756-762 Jean-François Boivin September 29th, 2010 1

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4. CASESCONTROLS 4

5. CASESCONTROLS 5

6. CASESCONTROLS INHALEDYES ON 758 1,039 63% x 21% x 758 = 1,039 = 478 218 280 821 ODDS RATIO = 478 x 821 = 6.4 218 x 280 6

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9. Globe and Mail 10 September 2010 9

10. New England Journal of Medicine 1999; 340: 603-608 10

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15. Archives of General Psychiatry 2010; 67: 889-894 15

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22. Robert H. Friss. Epidemiology for Public Heath Practice (2009); 368-369 22

23. Personality Disorders and Suicide Personality disorders are estimated to have been present in 30% of completed suicides and 40% of attempted suicides. Suicide occurs disproportionately in cluster B personality disorders. The rates of completed suicide in patients with borderline and antisocial personality disorders are 8% to 10% and 5%, respectively. Patients with borderline personality disorder have very high rates of suicide attempts (60%-75%). Self-injurious and self-mutilating behaviors are common in borderline personality disorder (e.g., cutting oneself) but much of the time do not represent suicide attempts. Cluster C personality disorders account for about 10% of completed suicides, and cluster A personality disorders account for less than 1% of completed suicides. 23

24. Personality Disorders and Suicide Personality disorders are estimated to have been present in 30% of completed suicides and 40% of attempted suicides. Suicide occurs disproportionately in cluster B personality disorders. The rates of completed suicide in patients with borderline and antisocial personality disorders are 8% to 10% and 5%, respectively. Patients with borderline personality disorder have very high rates of suicide attempts (60%-75%). Self-injurious and self-mutilating behaviors are common in borderline personality disorder (e.g., cutting oneself) but much of the time do not represent suicide attempts. Cluster C personality disorders account for about 10% of completed suicides, and cluster A personality disorders account for less than 1% of completed suicides. 24

25. 25 X 1% = X 1/1000 =

26. 26 16% 4% Risk in population = 100,000 = 9% 1,000,000 Relative risk = 16% ÷ 4% = 4 Population risk difference = 9% - 4% = 5% Risk difference = 16% - 4% = 12% Etiologic fraction (16% - 4%) ÷ 16% = 0.75 note: (relative risk -1) ÷ relative risk = (4 -1) ÷ 4 = 0.75 Population etiologic fraction (9% - 4%) ÷ 9% = 0.56 note: (relative risk -1) x % smokers in cases relative risk = 4 - 1 x 75,000 = 0.56 4 100,000

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