1. RAINBOW A comparative study of surgery for inflammatory bowel disease Ruth Blanco Colino, Tom Drake, Laura Gavagna, Camilla Kjeldsen, Samuel Lee

2. Why?  Inflammatory Bowel Disease is common  Outcomes  Young patients  Non-cancer research priority

3. Strengths  Defined, relatively low volume, population allows focussed data collection  Common Condition  Easily understood by students  Wide scope for future studies and involving students in European trials

4. Aims  To conduct a multicentre, high-quality prospective cohort study of surgical management for IBD across Europe  To determine risk-adjusted 30-day and 12-month outcomes of surgery for IBD

5. RAINBOW Patient Care Hypothesis Generation Clinical Evidence Education Trials Data Access Students into trials Incorporating students and early career doctors into trials Collaboration as a resource

6. Population  All patients undergoing resection for ulcerative colitis or Crohn’s disease

7. Primary Outcome 30 days + 12 months 30 days + 12 months Follow-up… Primary Outcome  Overall complication rate  Adjusted for variables prior to index event of operation

8. Secondary Outcomes 30 days + 12 months 30 days + 12 months Follow-up… Secondary Outcomes  Specific Complications: -Venous Thromboembolism -Infectious complications -Anastomotic leakage -Stoma complications  Pathological quality of resection  Disease Recurrence  Length of stay  Reoperation  Readmission

9. IBD disease activity Role of perioperative biologic therapy Prognostic Blood Tests Faecal Calprotectin Perioperative nutrition Surgical technique & emergency Proposed Outputs

10. Scope for ‘plug-in’ studies  Quality of Life Outcomes -IBDQ-9 -EQ-5D  Patient Reported Outcome Measures  Psychological repercussions -Body image -Depression

11. Summary FUTU RE TRIA LS EASY TO CONTR OL RESEARC H PRIORIT Y LOTS OF PATIEN TS

12. Thank you Any questions? ?