1. The Genetics of Sickle Cell Anaemia By Katie Ridewood

2. What is Sickle Cell Anaemia? A disorder that effects haemoglobin Red blood cells are “sickle shaped” Normal RBC – biconcave Sickle cell

3. What’s the effect of this sickle shape?

4. How does it affect people? Anaemia Severe pain Damage to organs such as: Liver, Kidney, Lungs, Heart & Spleen

5. How do you get Sickle Cell Anaemia? Genetic disorder Incomplete recessive gene for the coding of sickle haemoglobin. 2 recessive genes required to be sickle cell. Sickle Cell trait

6. Inheriting Sickle Cell

7. Outcomes RR Both alleles coded correctly No sickle cell anaemia ‘rr’ Both alleles coded for incorrect haemoglobin Will suffer from sickle cell anaemia Likely to die before 20.

8. Sickle Cell Trait Rr One allele for correct haemoglobin One allele for sickle cell haemoglobin Co-dominant

9. Sickle cell trait X “normal” Male: RR Female Rr

11. Eradication of Sickle Cell… 1 in 500 African Americans 1 in 100 Africans In Africa

12. Sickle Cell Vs Malaria Parasites use red blood cells as hosts Sickle cells die Parasites trapped Infection reduced

13. Gene Pool Homozygous “normal” haemoglobin Suffer from Malaria  Homozygous sickle cells Suffer from Sickle Cell anaemia  Heterozygous people Don’t suffer enough from either illness

14. Sickle Cell & Malaria

15. Bibliography & References www.sicklecellsociety.org http://www.lbl.gov/MicroWorlds/xfiles/malariawhati s.html http://www.lbl.gov/MicroWorlds/xfiles/malariawhati s.html http://chroma.gs.washington.edu/outreach/genetic s/sickle/sickle-back.html http://chroma.gs.washington.edu/outreach/genetic s/sickle/sickle-back.html http://www.wellesley.edu/Chemistry/Adele/Chem2 22/Syllabus/Links/bindprotns/malaria.html http://www.wellesley.edu/Chemistry/Adele/Chem2 22/Syllabus/Links/bindprotns/malaria.html http://www.lbl.gov/MicroWorlds/xfiles/malariawhati s.html