1. CHAPTER 6: MANAGEMENT OF ANAEMIA IN PATIENTS ON DIALYSIS Philip N. Jeremiah Bee Boon Cheak Ghazali B Ahmad Lim Soo Kun Zawawi B Nordin Source: 21 st MDTR Report 2013, NRR

2. Table 6.1.1: Treatment for anaemia, HD patients 2004-2013 Year Number of patients % on ESAs % received blood transfusion % on oral iron % received parenteral iron 2004 806374118010 2005 934381147411 2006 1167883187616 2007 1290785157417 2008 1540388166323 2009 1797789155926 2010 1950990145726 2011 2229690145528 2012 2567190145630 2013 2889891125434 Source: 21 st MDTR Report 2013, NRR

3. Table 6.1.2: Treatment for anaemia, PD patients 2004-2013 Year Number of patients % on ESAs % received blood transfusion % on oral iron % received parenteral iron 2004 13126315857 2005 13907212878 2006 155274168313 2007 180674168012 2008 208477167712 2009 221276167414 2010 236078167312 2011 255178187211 2012 287680186911 2013 326180177014

4. Source: 21 st MDTR Report 2013, NRR Table 6.1.3: Variation in Erythropoiesis-Stimulating Agents (ESAs) utilization (% patients) among HD centres, 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 21994065778597100 2005 241854748291100 2006 288355798793100 2007 320663828994100 2008 3773367859196100 2009 427871869296100 2010 4601673869296100 2011 514475879397100 2012 5664077889297100 2013 6113176889297100

5. Source: 21 st MDTR Report 2013, NRR Figure 6.1.3: Variation in ESAs utilization (% patients) among HD centres, 2013

6. Source: 21 st MDTR Report 2013, NRR Table 6.1.4: Variation in ESAs utilization (% patients) among PD centres, 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 18555563.57497 2005 1940 62698197 2006 2235536774869697 2007 2304464769097100 2008 24205970.57986.5100 2009 253056738087100 2010 2655638084.595100 2011 274465758793100 2012 28516782.587.593100 2013 2861648186.594100

7. Source: 21 st MDTR Report 2013, NRR Figure 6.1.4: Variation in ESAs utilization (% patients) among PD centres, 2013

8. Source: 21 st MDTR Report 2013, NRR Table 6.1.5: Variation in mean weekly ESAs dose (u/week) among HD centres, 2004-2013 Year Number of centres MeanSDMin 5 th centile LQMedianUQ 95 th centile Max 2004 181246364419292000 2191266738084929 2005 219350218732000 226529294066640016000 2006 2705130210320002800390947236044812520571 2007 3035302187120003143412550716108800017500 2008 361457011151935300038004480518265298632 2009 40347529012444337241484778525763088154 2010 440508911132200337844005011574372068240 2011 4895105113120003412435350005788716711046 2012 552519111402105345243405084593474099164 2013 5985339149222863486436150966097778316364

9. Source: 21 st MDTR Report 2013, NRR Figure 6.1.5: Variation in mean weekly ESAs dose (u/week) among HD centres, 2013

10. Source: 21 st MDTR Report 2013, NRR Table 6.1.6: Variation in mean weekly ESAs dose (u/week) among PD centres, 2004-2013 Year Number of centres MeanSDMin5 th centileLQMedianUQ 95 th centile Max 2004 1726004292074 2400260026963958 2005 18344315812000 2308266841247371 2006 21465311732308266740915045548059186373 2007 22497110153250342941515058570264717044 2008 2245469712556295238524481534460516239 2009 2343599202364272040474605480052356541 2010 2543849522364272740134263499360666429 2011 27437411201909195538164557504054467000 2012 2745238792500263640744603504457786208 2013 2844069242091261538874545519156805683

11. Source: 21 st MDTR Report 2013, NRR Figure 6.1.6: Variation in mean weekly ESAs dose (u/week) among PD centres 2013

12. Source: 21 st MDTR Report 2013, NRR Table 6.1.7: Variation in use of blood transfusion (% patients) among HD centres, 2004-2013 Year Number of centres Min5 th centileLQMedianUQ95 th centileMax 2004 2190027173548 2005 24100510194064 2006 28802916254273 2007 3200071321.537.552 2008 37700714233988 2009 42700612203855 2010 46000611193573 2011 51400611.5193267 2012 56600612193570 2013 61100610173467

13. Source: 21 st MDTR Report 2013, NRR Figure 6.1.7: Variation in use of blood transfusion (% patients) among HD centres, 2013

14. Source: 21 st MDTR Report 2013, NRR Table 6.1.8: Variation in use of blood transfusion (% patients) among PD centres, 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 1800514.52037 2005 19003101741 2006 2204916223541 2007 23671015233336 2008 24237.514233336 2009 2500814222931 2010 2600814213133 2011 2723915214246 2012 2803713.520.53139 2013 2867913.521.533

15. Source: 21 st MDTR Report 2013, NRR Figure 6.1.8: Variation in use of blood transfusion (% patients) among PD centres, 2013

16. Source: 21 st MDTR Report 2013, NRR Table 6.2.1: Distribution of serum ferritin without ESAs, HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 2004 1042590.7463.6473.5218910.58977 2005 1010618.5498.7485.52259029077 2006 1169562.4485.6408193.8817.58774 2007 1182586501431196860.98675 2008 1186578489.9431.9197838.18775 2009 1283546.6461.7419.71717988771 2010 1387510454.2372159.7755.68469 2011 1562499.6441.3375164702.58470 2012 1674480.9440.8344.8146.9671.78367 2013 1962462.6423.7324.21426588266

17. Source: 21 st MDTR Report 2013, NRR Figure 6.2.1: Cumulative Distribution of serum ferritin without ESAs, HD patients 2004-2013

18. Source: 21 st MDTR Report 2013, NRR Table 6.2.2: Distribution of serum ferritin without ESAs, PD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 2004 303608.4385.7522.73308829485 2005 225651.4397.8609324913.39688 2006 263589.9411.3484280815.89585 2007 305636.9396.6582.3342.8841.99687 2008 338634410.1592327.48419386 2009 364621.6401.1553322.5861.89586 2010 382624.9446.6523.5287.4875.89383 2011 435604.7407.4500316.9806.89588 2012 467557.5398.8456.8260.4743.99683 2013 486587.6407.3487.9298.3767.59583

19. Source: 21 st MDTR Report 2013, NRR Figure 6.2.2: Distribution of serum ferritin without ESAs, PD patients 2004-2013

20. Source: 21 st MDTR Report 2013, NRR Table 6.2.3: Distribution of serum ferritin on ESAs, HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 2004 3903669.8460.55713069779486 2005 5116682.7471599.5315.3971.59385 2006 6764640.3459543.1291.1881.19384 2007 8032658.8452.2564.4315.59149486 2008 9937703.6469.2611.1337.5979.59587 2009 12241679.3459.6596319.3941.99486 2010 13597679.4470581.83129589485 2011 15871653.5461.1551.5297913.39384 2012 18135627.6450527.8280879.39383 2013 20783606448.3500.3263838.99282

21. Source: 21 st MDTR Report 2013, NRR Figure 6.2.3: Cumulative distribution of serum ferritin on ESAs, HD patients 2004-2013

22. Source: 21 st MDTR Report 2013, NRR Table 6.2.4: Distribution of serum ferritin on ESAs, PD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 2004 540728.8427.2655.6406.3986.79892 2005 767732.9433.6659403.6997.59792 2006 888729.9435.6638.4399.5986.29894 2007 1091741.3426.1652423.810159894 2008 1310758.4445.4668.6422.41030.39893 2009 1390759.5438.7689421.11017.59893 2010 1554753.3438677.1426.31005.59793 2011 1631726.4436.4644.7403.3993.79791 2012 1899707.4440.2640.8375.6951.59690 2013 2139705.1448.9611.5362.7966.39789

23. Source: 21 st MDTR Report 2013, NRR Figure 6.2.4: Cumulative distribution of serum ferritin on ESAs, PD patients 2004-2013

24. Source: 21 st MDTR Report 2013, NRR Table 6.2.5: Distribution of transferrin saturation without ESAs, HD patients, 2004-2013 Year Number of patients MeanSDMedianLQUQ% Patients ≥ 20 % 2004 103141.218.137.528.550.192 2005 110637.717.834.425.646.287 2006 114936.216.932.924.744.287 2007 120636.116.532.52543.787 2008 121134.315.531.823.741.485 2009 128334.315.931.32440.885 2010 144233.515.630.422.740.583 2011 156732.414.729.822.938.485 2012 185932.414.529.922.838.783 2013 210531.21428.92237.381

25. Source: 21 st MDTR Report 2013, NRR Figure 6.2.5: Cumulative distribution of transferrin saturation without ESAs, HD patients 2004-2013

26. Source: 21 st MDTR Report 2013, NRR Table 6.2.6: Distribution of transferrin saturation without ESAs, PD patients, 2004-2013 Year Number of patients MeanSDMedianLQUQ% Patients ≥20 % 2004 37944.518.241.630.955.598 2005 28740.616.237.829.448.295 2006 29940.517.437.927.347.395 2007 34840.317.936.627.548.292 2008 34938.217.834.326.244.491 2009 43938.418.236.126.445.787 2010 44138.317.835.125.945.389 2011 42436.815.833.226.545.590 2012 49835.615.733.824.943.985 2013 46337.315.73426.144.491

27. Source: 21 st MDTR Report 2013, NRR Figure 6.2.6: Cumulative distribution of transferrin saturation without ESAs, PD patients 2004-2013

28. Source: 21 st MDTR Report 2013, NRR Table 6.2.7: Distribution of transferrin saturation on ESAs, HD patients, 2004-2013 YearNumber of patientsMeanSDMedianLQUQ% Patients ≥20 % 2004 326939.61736.127.848.193 2005 480836.617.232.824.64587 2006 638435.116.431.624.142.187 2007 760434.715.431.624.441.688 2008 953734.715.431.52441.687 2009 118543415.430.923.840.586 2010 13761341530.924.140.287 2011 1621432.614.329.723.138.785 2012 1897231.713.529.222.937.585 2013 21861311328.722.636.884

29. Source: 21 st MDTR Report 2013, NRR Figure 6.2.7: Cumulative distribution of transferrin saturation on ESAs, HD patients 2004-2013

30. Source: 21 st MDTR Report 2013, NRR Table 6.2.8: Distribution of transferrin saturation on ESAs, PD patients, 2004-2013 YearNumber of patientsMeanSDMedianLQUQ% Patients ≥20 % 2004 69744.718.740.830.854.596 2005 82043.519.339.129.453.795 2006 91641.617.53829.450.795 2007 108039.317.635.326.947.392 2008 126538.617.934.426.247.191 2009 155039.117.335.426.947.592 2010 162838.917.535.526.747.391 2011 167336.515.534.125.444.888 2012 193236.214.53426.643.890 2013 199537.414.734.427.244.493

31. Source: 21 st MDTR Report 2013, NRR Figure 6.2.8: Cumulative distribution of transferrin saturation on ESAs, PD patients 2004-2013

32. Source: 21 st MDTR Report 2013, NRR Table 6.2.9(a): Variation in Medium serum ferritin among patients on ESAs, HD centres 2004-2013 Year Number of centres Min5 th centileLQMedianUQ95 th centileMax 2004 12599.5324.8454.8563.5716.3981.52000 2005 1631.6322.54616257319672000 2006 2051.5234.5419.5553.7691.3914.52000 2007 24278.3256436566681880.51573 2008 27892.2332.6478600.7723.39491402 2009 34189.1301.2457594.7714.58941532.3 2010 37139255441575.5730969.41236.5 2011 43127240418.3535.5686904.31210.5 2012 493100.3241.9385.5517.3653884.51301.7 2013 527127.3231378.9496620.5858.11263.3

33. Source: 21 st MDTR Report 2013, NRR Figure 6.2.9(a): Variation in medium serum ferritin among patients on ESAs, HD centres 2013

34. Source: 21 st MDTR Report 2013, NRR Table 6.2.9(b): Proportion of patients on ESAs with serum ferritin ≥100 ng/ml, HD centres 2004-2013 YearNo. of centresMin5 th centileLQMedianUQ95 th centileMax 2004 12550859296100 2005 1636809095100 2006 2050759195100 2007 24236769196100 2008 27844819296100 2009 34144829195100 2010 37118799196100 2011 43115768995100 2012 49351768995100 2013 5276075889498100

35. Source: 21 st MDTR Report 2013, NRR Figure 6.2.9(b): Variation in proportion of patients on ESAs with serum ferritin ≥100 ng/ml, HD centres 2013

36. Source: 21 st MDTR Report 2013, NRR Table 6.2.9(c): Median transferrin saturation among patients on ESAs, HD centres 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 11522.727.23335.941.45266.8 2005 14817.325.129.132.337.848.969.8 2006 18013.723.728.131.436.546.181.3 2007 21517.62227.931.435.842.878.1 2008 25716.523.727.831.634.246.275.8 2009 30617.221.927.530.534.141.278.6 2010 35415.322.627.631.133.940.475.7 2011 42415.322.626.529.632.738.658.5 2012 48512.622.426.428.73237.343.9 2013 53116.222.125.428.531.336.670.6

37. Source: 21 st MDTR Report 2013, NRR Figure 6.2.9(c): Variation in median transferring saturation among patients on ESAs HD centres, 2013

38. Source: 21 st MDTR Report 2013, NRR Table 6.2.9(d): Proportion of patients on ESAs with transferrin saturation ≥ 20%, HD centres 2004-2013 Year Number of centres Min5 th centileLQMedianUQ95 th centileMax 2004 11567739094100 2005 1494269839195100 2006 1812064819095100 2007 2162763839096100 2008 2592567819095100 2009 3103663808894100 2010 3572464818994100 2011 4312762798693100 2012 4902760778794100 2013 5352961768693100

39. Source: 21 st MDTR Report 2013, NRR Figure 6.2.9(d): Variation in proportion of patients on ESAs with transferring saturation ≥ 20%, HD centres, 2013

40. Source: 21 st MDTR Report 2013, NRR Table 6.2.10(a): Variation in medium serum ferritin among patients on ESAs, PD centres 2004-2013 Year Number of centres Min5 th centileLQMedianUQ95 th centileMax 2004 13317 529.5610701.3860.3 2005 17338.5 557.2709.9800.9843 2006 19391.2 531633.5783.4968.4 2007 21290.3349.5589.6636.2716.3961.71048.6 2008 21329.7385499656.3820.9970.1979 2009 21329.4341.3578.8676.6784.99471157 2010 24266.5306568654.8752.4799827.5 2011 26203.1362.2598636.7783.8830.5923.8 2012 26158.3205.7519.5629.4741.3870.51038.5 2013 27182.9318501.7607.9724.7917.6991.7

41. Source: 21 st MDTR Report 2013, NRR Figure 6.2.10(a): Variation in medium serum ferritin among patients on ESAs, PD centres 2013

42. Source: 21 st MDTR Report 2013, NRR Table 6.2.10(b): Proportion of patients on ESAs with serum ferritin ≥100 ng/ml, PD centres 2004-2013 Year Number of centres Min5 th centileLQMedianUQ95 th centileMax 2004 1394 95100 2005 1788 9697100 2006 1995 98100 2007 2190929698100 2008 2188899398100 2009 2185869598100 2010 24858795.59899100 2011 2684 9297100 2012 2665839496.598100 2013 277888939899100

43. Figure 6.2.10(b): Variation in proportion of patients on ESAs with serum ferritin ≥ 100ng/ml, PD centres 2013 Source: 21 st MDTR Report 2013, NRR

44. Table 6.2.10(c): Median transferrin saturation among patients on ESAs, PD centres 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 1729.1 3640.942.782.3 2005 1730.3 36.338.54374.9 2006 1931.9 34.837.74274.9 2007 1926.1 29.437.74383 2008 1925.3 31.534.242.681.1 2009 222526.733.137.244.654.983.2 2010 2223.924.832.635.742.253.178.1 2011 2422.423.930.533.636.948.656.1 2012 25 26.630.53336.245.245.7 2013 2428.129.831.534.436.942.155.1

45. Source: 21 st MDTR Report 2013, NRR Figure 6.2.10(c): Variation in median transferrin saturation among patients on ESAs, PD centres 2013

46. Source: 21 st MDTR Report 2013, NRR Table 6.2.10(d): Proportion of patients on ESAs with transferring saturation ≥20%, PD centres 2004-2013 YearNumber of centresMin5 th centileLQMedianUQ95 th centileMax 2004 1788 9697100 2005 1788 9397100 2006 1983 939598100 2007 1974 889498100 2008 1965 919597100 2009 2270839294.597100 2010 2269759095100 2011 245968859497.5100 2012 256272869497100 2013 24788389.59397100

47. Source: 21 st MDTR Report 2013, NRR Figure 6.2.10(d): Variation in proportion of patients on ESAs with transferrin saturation ≥20 %, PD centres 2013

48. Source: 21 st MDTR Report 2013, NRR Table 6.3.1: Distribution of haemoglobin concentration without ESAs, HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 192510.12.29.98.611.5532819 2005 166710.52.310.38.912.1462925 2006 176010.62.210.5912.1423226 2007 175610.82.210.79.112.4402931 2008 175110.82.310.89.112.6392932 2009 184811.22.311.39.412.9332938 2010 187511.22.211.49.612.930 40 2011 207111.22.211.49.612.8313039 2012 228511.42.211.79.913263143 2013 254211.42.211.71013263044

49. Source: 21 st MDTR Report 2013, NRR Figure 6.3.1: Cumulative distribution of haemoglobin concentration without ESAs, HD patients 2004-2013

50. Source: 21 st MDTR Report 2013, NRR Table 6.3.2: Distribution of haemoglobin concentration without ESAs, PD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 48110.41.610.39.411.4424315 2005 37510.81.610.89.911.8285220 2006 38710.91.610.91011.8255520 2007 43611.11.61110.212.1225127 2008 45011.11.711.110.212.1215128 2009 48811.11.811.110.112.2254728 2010 49511.11.711.19.912.2274627 2011 54711.11.611.11012.1254827 2012 56511.21.711.110.112.3254629 2013 61011.31.611.210.312.3194932

51. Source: 21 st MDTR Report 2013, NRR Figure 6.3.2: Cumulative distribution of haemoglobin concentration without ESAs, PD patients 2004-2013

52. Source: 21 st MDTR Report 2013, NRR Table 6.3.3(a): Distribution of haemoglobin concentration on ESAs, diabetes HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 21899.81.59.78.710.857358 2005 2890101.69.98.911523810 2006 4084101.69.98.91153389 2007 465710.11.510.1911.1484210 2008 588510.11.510.1911.2474310 2009 734410.21.510.39.211.3444511 2010 812810.31.510.49.311.4424612 2011 931210.31.510.49.311.4414712 2012 1088510.21.510.39.311.3424711 2013 1211810.31.510.49.311.3414811

53. Source: 21 st MDTR Report 2013, NRR Figure 6.3.3(a): Cumulative distribution of haemoglobin concentration on ESAs, diabetes HD patients 2004-2013

54. Source: 21 st MDTR Report 2013, NRR Table 6.3.3(b): Distribution of haemoglobin concentration on ESAs, non-diabetes HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 36169.91.69.98.81153389 2005 432710.11.610.18.911.2484012 2006 533010.11.610.19.111.2474112 2007 603910.31.610.49.311.4414613 2008 715310.31.510.49.211.4414712 2009 819010.31.510.59.311.4404812 2010 896510.41.510.59.411.5384913 2011 1026810.31.510.59.411.4394912 2012 1179810.31.510.49.311.4395011 2013 1350010.31.510.59.411.4385012

55. Source: 21 st MDTR Report 2013, NRR Figure 6.3.3(b): Cumulative distribution of haemoglobin concentration on ESAs, non-diabetes HD patients 2004-2013

56. Source: 21 st MDTR Report 2013, NRR Table 6.3.4(a): Distribution of haemoglobin concentration on ESAs, diabetes PD patients 2004-2013 Year Number of subject MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 22410.21.610.29.111.3464014 2005 26710.31.610.39.311.543 14 2006 33410.21.410.39.411.1434710 2007 45910.51.310.49.611.4375112 2008 62910.51.310.69.611.4335512 2009 65210.51.410.69.611.4355312 2010 62010.51.410.59.511.4375013 2011 59310.41.410.59.611.4365311 2012 66810.41.410.59.611.337549 2013 71610.41.410.59.511.3375310

57. Source: 21 st MDTR Report 2013, NRR Figure 6.3.4(a): Cumulative distribution of haemoglobin concentration on ESAs, diabetes PD patients 2004-2013

58. Source: 21 st MDTR Report 2013, NRR Table 6.3.4(b): Distribution of haemoglobin concentration on ESAs, non-diabetes PD patients 2004-2013 YearNumber of subjectMeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 2004 5749.71.79.68.410.957349 2005 7039.81.79.78.611563311 2006 7849.91.69.98.811523810 2007 86010.21.710.3911.4444115 2008 94810.21.610.39.211.344 12 2009 101210.21.610.39.211.444 12 2010 118510.21.610.39.111.3444511 2011 134910.11.510.29.111.246459 2012 158210.31.510.39.211.3434611 2013 184910.21.510.39.211.2444610

59. Source: 21 st MDTR Report 2013, NRR Figure 6.3.4(b): Cumulative distribution of haemoglobin concentration on ESAs, non-diabetes PD patients 2004-2013

60. Source: 21 st MDTR Report 2013, NRR Table 6.3.5(a): Variation in median haemoglobin level among patients on ESAs, HD centres 2004-2013 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 2004 1797.68.69.29.810.210.911.3 2005 2168.38.89.49.910.411.111.5 2006 2677.78.89.59.910.511.312.6 2007 3028.69.29.810.210.611.212.2 2008 3558.199.810.210.711.311.9 2009 4018.59.19.910.310.811.412.2 2010 4388.19.29.910.410.911.412.1 2011 4958.39.19.910.410.811.412.2 2012 5518.299.810.410.811.311.8 2013 5978.39.19.910.410.811.311.8

61. Source: 21 st MDTR Report 2013, NRR Figure 6.3.5(a): Variation in median haemoglobin level among patients on ESAs, HD centres 2013

62. Source: 21 st MDTR Report 2013, NRR Table 6.3.5(b): Proportion of patients on ESAs with haemoglobin level > 10g/dL, HD centres 2004-2013 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 2004 1797173142577385 2005 2160183348.5617688 2006 2670213648628094 2007 30292943566783100 2008 35502543566982100 2009 40142846587086100 2010 438122947607287100 2011 49502847607188100 2012 55102546607083100 2013 5974284860718596

63. Source: 21 st MDTR Report 2013, NRR Figure 6.3.5(b): Variation in proportion of patients on ESAs with haemoglobin level > 10g/dL, HD centres 2013

64. Source: 21 st MDTR Report 2013, NRR Table 6.3.6(a): Variation in Median haemoglobin level among patients on ESAs, PD centres 2004-2013 Year Number of centres Min5 th centileLQMedianUQ 95 th centile Max 2004 178.4 9.29.710.211.2 2005 188.9 9.69.810.311 2006 228.78.99.49.910.410.610.9 2007 229.5 10.110.310.811.1 2008 229.29.610.210.410.611.111.2 2009 239.49.59.910.610.71111.2 2010 259.39.510.210.410.611.211.3 2011 278.699.910.310.610.911 2012 279.39.49.810.410.611.111.2 2013 289.49.69.910.310.510.911.3

65. Source: 21 st MDTR Report 2013, NRR Figure 6.3.6(a): Variation in median haemoglobin level among patients on ESAs, PD centres 2013

66. Source: 21 st MDTR Report 2013, NRR Table 6.3.6(b): Proportion of patients on ESAs with haemoglobin level >10g/dL, PD centres 2004-2013 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 2004 1711 38435272 2005 1821 3547.55676 2006 2219204348.5586970 2007 2235365259.56372 2008 2232365760.5647589 2009 2334384861677176 2010 2536375058657377 2011 2717224958687980 2012 2736384461667785 2013 28 4046.558.563.57181

67. Source: 21 st MDTR Report 2013, NRR Figure 6.3.6(b): Variation in proportion of patients on ESAs with haemoglobin level >10g/dL, PD centres, 2013