1. High-throughput Sequencer Dec 2011 – 758 sequencers Apr 2012 – 823 sequencers Biomedical Research 1 – © 2012 Internet2 Source: http://omicsmaps.com/, Dec. 5, 2011http://omicsmaps.com/ Increasing at 25% per year Image: Illumina

2. Ion Proton Sequencer Democratization of Sequencing 2 – © 2012 Internet2 Handheld USB Sequencer Image: Oxford Nanopore Technologies Image: Life Technologies

3. Source: L. D. Stein Genome Biol. 11, 207 (2010) Moving beyond Moore’s Law 3 – © 2012 Internet2

4. Research Centers Who’s Who 4 – © 2012 Internet2 University VP / CIO Medical School CIO Academic Medical Center CIO Cancer Center CIO Genomics Center CIO Who does research involving Big Data? Who does wide area networking? Who talks with whom? Who is responsible for security? Who is collaborative? Who is in charge?

5. ESnet Science DMZ for Biomedical Researchers 5 – © 2012 Internet2 Sensitive data –PHI –Limited data set –De-identified Security –ACLs in DMZ switch –Server hardening –Firewall issues –Encryption –Best practices guide Source: http://fasterdata.es.net/science-dmz/science-dmz-architecture/

6. What do biomedical researchers need today? Tomorrow? Who are the collaborative early adopters? How can we disseminate best practices? –Training the trainer workshops –Educational materials –Performance monitoring and troubleshooting –ESnet’s Science DMZ architecture –Security recommendations What is unique in the life sciences? –Security Issues –Transport protocols –International collaborations Engaging Biomedical Researchers 6 – © 2012 Internet2