1. © Copyright ASD GmbH 2006 ASD ASD Advanced Simulation & Design GmbH Virtual product development in medical technology and engineering www.ASD-online.com Multi-level modelling in the design of cardiovascular treatments Catrin Bludszuweit-Philipp ICT BIO Conference 2006

2. © Copyright ASD GmbH 2006 Outline 1ASD competencies 2challenges for endovascular device design 3multilevel endovascular device analysis 4virtual stenting platform in @neurIST

3. © Copyright ASD GmbH 2006 ASD - expert simulation services Complex system analysis

4. © Copyright ASD GmbH 2006 Simulations for medical devices mimic reality closely benefit treatment reduce costs and time-to-market understand needs and demands from industry and medical community: Two main tasks for simulation experts: give insights and motivations for use of modern technologies

5. © Copyright ASD GmbH 2006 Challenges for endovascular devise design excellent mechanical properties (flexibility, strength, durability) haemodynamically alligned non-damaging to vascular wall thrombosis - controllable local drug-provider adaptable to patient anatomy & conditions Aims: Optimisation and customisation of endovascular devices:

6. © Copyright ASD GmbH 2006 Multilevel endovascular device analysis Haemodynamics Vascular wall mechanics Device design Device mechanics Biological response Thrombosis Chemical processes Drug delivery Genetics Cardiovascular systems Patient-specific anatomies Multilevel stent / coil analysis

7. © Copyright ASD GmbH 2006 anatomymeshexpand stent into mesh 1D - model wall mechanics flow simulating interaction with wall aneurysm biological responses (thrombosis + aneurysm rupture) virtual optimisation of treatment, device design & operation planning Just a dream? Multilevel endovascular device analysis

8. © Copyright ASD GmbH 2006 Developing of IT infrastructure for managing and processing of heterogeneous data associated with the diagnosis and treatment of cerebral aneurysms and subarachnoid haemorrage. Integrative suite within @neurIST: virtual stenting and coiling of patient-specific anatomies @neuEndo virtual stenting and coiling of patient-specific anatomies Consolidation of competencies in @neurIST: Make the dream become true! Multilevel endovascular device analysis

9. © Copyright ASD GmbH 2006 Thank you very much for your attention

10. © Copyright ASD GmbH 2006 Patient-specific anatomies inflow outflow aneurysm patient-specific geometry generation of numerical grid

11. © Copyright ASD GmbH 2006 Cardiovascular System 1D compartmental model 1D compartmental model Transient pressure profil in the arterial system predicted by the 1D compartmental model

12. © Copyright ASD GmbH 2006 Haemodynamics Prediction of flow field in cerebral aneurysms by CFD analysis Prediction of flow field in cerebral aneurysms by CFD analysis blood vessel flow direction aneurysm stream lines wall shear stress flow direction aneurysm

13. © Copyright ASD GmbH 2006 Vascular wall mechanics Development of constitute equations for the tissue Development of constitute equations for the tissue Load-dependent tissue remodelling Load-dependent tissue remodelling Simulation of local weakening and mechanical failure Simulation of local weakening and mechanical failure

14. © Copyright ASD GmbH 2006 Device Design & Analysis of Device Mechanics FE-Analysis of Stent expansion Analysis of mechanical failure (e.g. buckling, life time prediciton) Analysis of mechanical failure (e.g. buckling, life time prediciton) Interaction of endovascular devices with the flow field Interaction of endovascular devices with the flow field Analysis of thrombosis risk Analysis of thrombosis risk Estimation of drug delivery Estimation of drug delivery Simulation of drug elution Simulation of drug elution Transfer of flow-induced forces Transfer of flow-induced forces wall shear stress velocity mass transfer rate concentration

15. © Copyright ASD GmbH 2006 Thrombosis Deposited activated platelets Increased deposition in regions of long exposure times Centrifugal blood pump high shear forces thrombotic materials flow stagnation white and red thrombi Thrombosis Modelling: starting thrombus growth platelet deposition and thrombus growth