2. AP Biology Agenda for 3/19  Cell Communication Booklet Review using PPT  “My Dog is Broken”  Organize work and concept mapping That’s life- Why you and your iPod must die ~ due Monday Behavior booklet due Wednesday Mini-test _____– Development, Nervous System and Cell Communication

3. AP Biology Agenda for 3/20  Complete Cell Communication Booklet Review  My Dog is Broken - Case Study  Cell Signaling Project Assignment

4. AP Biology A. Cell Signaling  Yeast cells  Identify their mates by cell signaling  factor Receptor Exchange of mating factors. Each cell type secretes a mating factor that binds to receptors on the other cell type. 1 Mating. Binding of the factors to receptors induces changes in the cells that lead to their fusion. New a/  cell. The nucleus of the fused cell includes all the genes from the a and  cells. 2 3  factor Yeast cell, mating type a Yeast cell, mating type    a/  a a Figure 11.2

5. AP Biology Water and Mineral Absorption – Water Transport in Roots Apoplastic or symplastic Until the endodermis Is reached!!

6. AP Biology Translocation of Phloem Sap- Loading of Sugars  Flow through the symplast or apoplast in mesophyll cells into sieve-tube members  Active co-transport of sucrose with H +  Proton pump

7. AP Biology Cell Junctions

8. AP Biology Regulation & Communication  Animals rely on 2 systems for regulation  endocrine system  system of ductless glands  secrete chemical signals directly into blood  chemical travels to target tissue  target cells have receptor proteins  slow, long-lasting response  nervous system  system of neurons  transmits “electrical” signal & release neurotransmitters to target tissue  fast, short-lasting response

9. AP Biology Short Distance w/chemical messengers axon endocrine gland receptor proteins target cell  Neurotransmitters released by neurons  Hormones release by endocrine glands receptor proteins hormone carried by blood neurotransmitter Lock & Key system

10. AP Biology Paracrine Signaling on your tongue

11. AP Biology Nitric Oxide Signaling in the Penis and Heart

12. AP Biology Prostaglandin Signaling by Sperm in the Uterine Cells

13. AP Biology

14. 2007-2008 Endocrine System Hormones

15. AP Biology  Why are hormones needed?  chemical messages from one body part to another  communication needed to coordinate whole body  daily homeostasis & regulation of large scale changes  solute levels in blood  glucose, Ca ++, salts, etc.  metabolism  growth  development  maturation  reproduction Regulation growth hormones

16. AP Biology Lipid-based hormones  hydrophobic & lipid-soluble  diffuse across cell membrane & enter cells  bind to receptor proteins in cytoplasm & nucleus  bind to DNA as transcription factors  turn on genes  Structure  Steroids- modified cholesterol  testosterone-muscles, bone mass, body hair, testis and prostate development  estrogen – female development, menstrual cycle control (maintains lining of uterus)  Aldosterone – controls sodium and potassium balance and blood pressure

17. AP Biology Steroid Hormone

18. AP Biology nucleus target cell DNA mRNA protein blood protein carrier S S S S Action of lipid (steroid) hormones binds to receptor protein cytoplasm becomes transcription factor ex: secreted protein = growth factor (hair, bone, muscle, gametes) 2 4 6 cross cell membrane 1 steroid hormone mRNA read by ribosome 5 plasma membrane protein secreted 7 3

19. AP Biology Protein Based Hormones  hydrophilic & not lipid soluble  can’t diffuse across cell membrane  bind to receptor proteins in cell membrane  trigger secondary messenger pathway  activate internal cellular response  enzyme action, uptake or secretion of molecules…  Structure  polypeptides  small proteins: insulin, ADH  glycoproteins  large proteins + carbohydrate: FSH, LH  Amines-modified amino acids:  epinephrine – see example  melatonin – regulates sleep/wake cycle by lowering body temperature and causing drowsiness insulin

20. AP Biology Action of protein hormones activates enzyme activates enzyme activates enzyme ATP produces an action P 1 2 3 cytoplasm receptor protein response signal secondary messenger system signal-transduction pathway acts as 2° messenger target cell plasma membrane binds to receptor protein protein hormone ATP activates cytoplasmic signal cAMP GTP activates G-protein transduction

21. AP Biology adrenal gland Ex: Action of epinephrine (adrenaline) activates protein kinase-A activates glycogen phosphorylase activates adenylyl cyclase epinephrine liver cell released to blood 1 2 5 receptor protein in cell membrane cytoplasm 6 glycogen activates phosphorylase kinase GDP cAMP 4 activates G protein ATP glucose activates GTP 3 signal transduction response 7 GTP

22. AP Biology Benefits of a 2° messenger system Amplification! signal receptor protein Activated adenylyl cyclase amplification GTPG protein product enzyme protein kinase cAMP Not yet activated 1 2 4 3 5 6 7 FAST response! amplification Cascade multiplier!

23. AP Biology Negative Feedback Loop high low hormone 1 lowers body condition hormone 2 gland specific body condition raises body condition gland Negative Feedback Model

24. AP Biology liver pancreas liver Regulation of Blood Sugar blood sugar level (90mg/100ml) insulin body cells take up sugar from blood liver stores glycogen reduces appetite glucagon pancreas liver releases glucose triggers hunger high low Feedback Endocrine System Control islets of Langerhans beta islet cells islets of Langerhans alpha islet cells

25. AP Biology

26. Positive Feedback Loop

27. AP Biology Controlling Body Temperature high low nerve signals sweat nerve signals body temperature (37°C) shiver dilates surface blood vessels constricts surface blood vessels Nervous System Control Feedback hypothalamus

28. AP Biology

30. Quorum Sensing in Bacteria

31. AP Biology Nervous & Endocrine systems linked  Hypothalamus = “master nerve control center”  nervous system  receives information from nerves around body about internal conditions  releasing hormones: regulates release of hormones from pituitary  Pituitary gland = “master gland”  endocrine system  secretes broad range of “tropic” hormones regulating other glands in body hypothalamus pituitary posterior anterior

32. AP Biology Thyroid gland hypothalamus anterior pituitary gonadotropic hormones: follicle- stimulating hormone (FSH) & luteinizing hormone (LH) Mammary glands in mammals Muscles of uterus Kidney tubules posterior pituitary thyroid-stimulating hormone (TSH) antidiuretic hormone (ADH) Adrenal cortex Bone and muscle Testes Ovaries Melanocyte in amphibian adrenocorticotropic hormone (ACTH) melanocyte-stimulating hormone (MSH) oxytocin prolactin (PRL) growth hormone (GH) tropic hormones = target endocrine glands

33. AP Biology Homology in hormones prolactin mammals milk production birds fat metabolism amphibians metamorphosis & maturation fish salt & water balance growth & development What does this tell you about these hormones? growth hormone same gene family gene duplication? How could these hormones have different effects?

34. AP Biology