1. Modeling and Synthetic Biology DAY THREE: PART ONE

2. What is a model?

3. Model -Concrete -Descriptive -Abstract

4. Why build a model

5. Why Model? -Reveals relationships which were not previously apparent -Not possible to make a physical measurement -Large volume of data -Infeasible experiments -save cost/time

6. Criticism

7. Model -‘Of course your model predicted what you wanted to - you built it’ - ‘I could have figured it out without your model just by doing a simple experiment’

8. Types of models 1. Rule-based models 2. Mass action kinetics 3. Stoichiometric matrix

9. In class excercise

10. Model : Steps for Building 1.Graphical depiction 2.System definition (boundaries & assumptions) & data collection 3. Mathematical expressions 4. System analysis 5. Model curation - ‘I could have figured it out without your model just by doing a simple experiment’