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A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK.

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Presentation on theme: "A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK."— Presentation transcript:

1 A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK.

2 RAL December 5 th 2005

3

4

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6 To see small things – you need a big thing …

7 RAL December 5 th 2005 ’Neutrons (and muons) tell you where atoms are and what atoms do’ What can neutrons and muons do?

8 RAL December 5 th 2005 DiamondGraphiteFullerene

9 RAL December 5 th 2005 Neutron Diffraction

10 RAL December 5 th 2005

11 Inelastic Neutron Scattering

12 RAL December 5 th 2005 Time of flight method Particle Momentum – k (velocity) Energy - E WaveWavelength – λ (length scale) 1000 m/s 20 m μsμs 20 ms 10 -10 m

13 RAL December 5 th 2005

14

15 unique Neutrons see the world in a unique way Length and time scales 10 -11 – 10 -6 m 10 -14 – 10 -6 s From hydrogen … … to hydrogenase

16 RAL December 5 th 2005 unique Neutrons see the world in a unique way Length and time scales 10 -11 – 10 -6 m 10 -14 – 10 -6 s From hydrogen … … to hydrogenase

17 RAL December 5 th 2005 unique Neutrons see the world in a unique way

18 RAL December 5 th 2005 unique Neutrons see the world in a unique way Penetration Large samples, buried interfaces, non-destructive

19 RAL December 5 th 2005 unique Neutrons see the world in a unique way Magnetism The neutron has a magnetic moment but no charge

20 RAL December 5 th 2005 unique Neutrons see the world in a unique way + + = Sensistivity and selectivity Isotopic substitution/contrast variation

21 RAL December 5 th 2005 unique Neutrons see the world in a unique way a(4K) = 14.04212(2) Å 18 th order spherical harmonic c 18,1 = -0.020; c 18,2 = 0.077 Precision Weak interaction, simple interaction

22 RAL December 5 th 2005

23 Crystallography Powder diffraction HRPD POLARIS GEM HiPr (ROTAX) WISH (TS2) Single crystal diffraction SXD Engineering diffraction ENGIN-X

24 RAL December 5 th 2005 Single crystal diffraction - SXD

25 RAL December 5 th 2005 Anticancer drug studied on SXD in 2005 C. K. Broder et al.

26 RAL December 5 th 2005 Anticancer drug studied on SXD in 2005 C. K. Broder et al.

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