1. Bones: Structure & Function

2. Learning Objectives By the end of this class you should understand: The five functions of bones in the human body The structure and composition of compact and spongy bone The purposes of the different bone cells The processes of bone development, growth and repair The difference between the axial and appendicular skeletons

3. Skeletal System The skeletal system is an organ system composed of many connected body parts – Bones – Cartilage – Ligaments: attach bone to bone – Tendons: attach bone to muscle

4. Five Functions of Bone Support Protection Movement Blood production Mineral balance

5. Bone Tissue Bone is made from the following substances: – Calcium phosphate crystals (hardness) – Matrix of protein such as collagen (flexibility) – Living cells – Blood vessels to feed said cells – Marrow in the middle

6. Bone Structure Bones are incredibly strong due to their dual nature – Too hard: brittle, can crack/shatter – Too flexible: can’t support weight Bone is made from a combination of compact bone and spongy bone

7. Compact vs. Spongy Bone Compact bone: layers of dense bone material (crystals + matrix) wrapped around blood vessels Spongy bone: network of bone material filled with yellow or red marrow Many bones have a compact layer around a spongy center

8. Osteon Compact bone is made of many osteons An osteon is an arrangement of bone material around a blood vessel Many osteocytes (bone cells) produce and maintain the osteon

9. Spongy Bone Spongy bone is not made of osteons – The osteon is designed to maximize blood delivery to a densely packed tissue Spongy bone is filled with marrow – Red marrow: produces blood – Yellow marrow: stores fat

10. Bone Growth/Decay All bone growth and decay is managed by two competing types of cells Osteoblasts build new bone tissue Osteoclasts degrade/remove bone tissue

11. Osteoblasts “Blast” is a suffix for a cell that produces something – Fibroblasts produce fibrous connective tissue – Chondroblasts produce cartilage – Osteoblasts produce bone The fetus begins its skeleton as cartilage bones formed by chondroblasts

12. Osteoblast Activity Osteoblasts produce bones The first osteoblasts form in the cartilage of fetal cartilage- bones and create the bone Osteoblasts are slowly converting cartilage to bone even as adults – The sternum is 3 different bones in children but one fused bone in the elderly

13. Bone Growth The cartilage skeleton in fetuses is produced by chondroblasts – Osteoblasts convert the cartilage to bone Most bones have finished their shape early in childhood, but long bones (femur, etc) do not – They have a growth plate made of cartilage that allows them to continue to lengthen until age 18-21 – Defective growth plate can lead to dwarfism

14. Osteoblast Activity Osteoblasts grow more bone matrix throughout life – Responsible for thickening of bone in response to stress – Forensic analysis can determine whether someone was right- or left-handed!

15. Osteoclasts Osteoclasts break down bone material Release calcium into bloodstream when active – Low blood calcium stimulates osteoclasts to break down bones to replace calcium – Drink your milk! – Chronic low bone density can lead to osteoporosis in old age Wear down jagged edges of damaged bone

16. Bone Repair Damaged bone attracts chondroblasts to grow cartilage and knit the bone fragments together Osteoclasts wear down the damaged bone matrix Osteoblasts regrow the bone tissue thicker than it was before

17. Skeleton(s) The human skeleton is divided into two parts: Axial skeleton: head, torso, hips Appendicular skeleton: arms and legs

19. More on Wednesday!