1. Chapter 6 Contraction of Skeletal Muscle Dr. Marko Ljubković Department of Physiology

2. Anatomy of Skeletal Muscle Muscle fibers Myofibrils Sarcomeres

3. Sarcomere Myofibrils SR Anatomy of Skeletal Muscle

4. Actin and Myosin Filaments

5. Cross-bridge Cycle

6. Muscle Length-Force Relationship

7. Velocity-Load Relationship Determined by isotonic contraction

8. Sources of Energy for Contraction 1.ATP pool 2.Creatine phosphate 3.Carbohydrates Glycolysis Oxidative phosphorylation 4.Fatty acids β-oxidation Oxygen debt Strenuous ex. (mostly fast motor units) Endurance ex. (slow units) Fatigue Accumulation of lactic acid

9. Types of Muscle Fibers 1.Fast twitch fibers Thicker muscle fibers and nerves Extensive SR Abundance of glycolitic enzymes Lower mitochondrial content Different myosin isoform 2.Slow twitch fibers 3.Both types found in individual muscle

10. Mechanics of Muscle Contraction 1.Motor unit α-motor neuron + muscle fibers Small (100 to 500 fibers, slow twitch) and Large (1000 to 2000 fibers, fast twitch) 2.Recruitment Slow twitch units recruited first Spatial summation Temporal summation (frequency depends on muscle type)

11. Muscle Growth