1. Arturo Pinna Pintor Foundation - fondazione@pinnapintor.it * Mauriziano “Umberto I” Hospital – Turin - Italy Can preoperative antiplatelet treatment increase post- operative bleeding and the need for blood transfusions in cardiac surgery? S Colangelo, M Bobbio, M Giammaria, *C Comoglio, *F Parisi, *G Punta, *R Casabona, P Pinna Pintor XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000

2. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000

3. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy 253 patients 6 patients died 3 patients without CPB 15 patients with unspecified treatment withdrawal 16 patients reoperated for bleeding ______________________________ 213 patients XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000

4. 213 patients Group A: 84 patients, < 7 days Group B: 129 patients, > 7 days Variables considered Age Length of CPB Haemoglobin level ( 12 hours after the beginning of intervention) Chest tube drainage (4 and 12 hours after ICU admission) RBC and plasma units transfused Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000

5. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy

6. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy Age and length of CPB Group A Group B value (mean ± SD) XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 NS

7. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy Haemoglobin levels g/dl (mean ± SD) Group A Group B XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 NS 12th hours

8. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy Chest tube drainage ml (mean ± SD) Group A Group B XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 p=0.01

9. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy RBC and plasma units Group A Group B units (mean ± SD) XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 p=0.02 p<0.001

10. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy RBC and plasma units Group A Group B Hb level XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 Chest tube drainage

11. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy Multivariate analysis XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 1.01 to 1.031.02 Length of CPB (min) 1.02 to 1.101.06Age (years) 1.05 to 3.461.92 Late withdrawal (< 7 days) (95% CI)Odd ratios

12. Arturo Pinna Pintor Foundation * Mauriziano “Umberto I” Hospital – Turin - Italy Conclusions XXII ESC Annual Congress – Amsterdam The Netherlands – August 26-30, 2000 7 days of preoperative antiplatelet treatment withdrawal Minor postoperative bleeding Minor entity of blood transfusions