1. cellular macromolecule catabolism cellular macromolecule metabolism cytoplasm organization and biogenesis establishment of cellular localization intracellular receptor-mediated signaling pathway macromolecule metabolism organelle organization and biogenesis catabolism cell cycle cell cycle checkpoint cell division cell organization and biogenesis cellular catabolism cellular localization cellular metabolism cellular physiological process cellular process cellular protein catabolism cellular protein metabolism development intracellular protein transport intracellular signaling cascade intracellular transport macromolecule catabolism metabolism physiological process primary metabolism A. Non-medicatedMedicated

2. B.Non-medicated -100102030 negative regulation of cellular metabolism negative regulation of cellular physiological process negative regulation of metabolism negative regulation of nucleic acid metabolism negative regulation of transcription positive regulation of biological process positive regulation of cellular metabolism positive regulation of cellular process positive regulation of metabolism positive regulation of nucleic acid metabolism positive regulation of transcription positive regulation of transcription from RNA polymerase promoter positive regulation of transcription, DNA-dependent regulation of biological process regulation of cell cycle regulation of cellular metabolism regulation of cellular physiological process regulation of cellular process regulation of metabolism regulation of physiological process regulation of progression through cell cycle regulation of transcription from RNA polymerase II promoter -100102030 Medicated

3. 01234567 chromosome segregation DNA metabolism DNA recombination DNA repair DNA replication interphase M phase mitosis C. Non-medicated 01234567 chromatin modification chromosome segregation DNA metabolism DNA recombination DNA repair DNA replication interphase M phase mitosis Medicated

4. 012345 mRNA metabolism mRNA processing nuclear mRNA splicing, via spliceosome RNA metabolism RNA processing RNA splicing rRNA metabolism rRNA processing transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter transcription initiation D. Non-medicated 01234 5 Medicated

5. biopolymer catabolism biopolymer metabolism biopolymer modification establishment of protein localization modification-dependent protein catabolism protein amino acid ADP-ribosylation protein catabolism protein import protein kinase cascade protein localization protein metabolism protein modification protein targeting protein transport protein ubiquitination proteolysis during cellular protein catabolism 05101520 25 E. Non-medicated 0510152025 Medicated

6. F. 05101520 25 androgen receptor signaling pathway biological process unknown nuclear import nuclear transport nucleobase, nucleoside, nucleotide and nucleic acid metabolism nucleocytoplasmic transport response to DNA damage stimulus response to endogenous stimulus response to stress ribosome biogenesis ribosome biogenesis and assembly steroid hormone receptor signaling pathway ubiquitin cycle ubiquitin-dependent protein catabolism vesicle-mediated transport -5 0510152025 Non-medicatedMedicated