1. IMMUNOLOGY Doc. dr Dušan Popadić Doc. dr Miloš Marković Ass. dr Emina Savić Prof. dr Vera Pravica imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic

2. Welcome to Immunology Course

3. Advice for successful learning and passing the exam

4. Immunology Course (40 hours) Lectures (12 hrs) Practice (Seminars and Labs 28 hrs)

5. Seminars and Labs during first 14 weeks Lectures during first 12 weeks Seminars, Labs and Lectures are integral parts of the course Student are allowed to be absent on seminar or lab twice during the semester

6. In addition to these 40 hrs to prepare the exam you will need 60 hours of effective work Preparation for lectures and practice (15 hrs) Preparation of colloquium and final exam (45 hrs) Lectures (12 hrs) Practise (seminars and labs 28 hrs)

7. References Basic Immunology: Functions and Disorders of the Immune System - Authors: Abbas AK, Lichtman AH. - Publisher: Elsevier - 3 rd edition updated, 2011.ppt presentations and authorised supplementary material (available on web site)

8. activities on the course (seminars, labs and lectures) – through activity points Continuous assessment colloquium – partial, after every 4 weeks (5 th, 9 th and 13 th week) presence on lectures noted separately

9. Threshold for a pass is 31 points, max 60 points Test (multiple choice – 1 correct answer out of 4) - first: in the 5 th week - second: in the 9 th week - third: in the 13 th week Colloquium 15 minutes per mini test It consists of 30 questions in total (divided into 3 mini tests) 1 point for each answer, max 30 points Final exam Final test with combined multiple choice and short answer questions

10. Colloquium score (30%) Final exam mark (60%) Activity on seminars and labs (7%) Regularity of course attendance (3%) Final mark in Immunology

11. Final mark in Immunology (25%) February session → Final mark in Microbiology (75%) June session → Final mark in Microbiology and Immunology Pass in Immunology is a condition for starting the exam in Microbiology

12. Introduction to immune system Innate and adaptive immunity Types of adaptive immunity Properties and phases of adaptive immune response Central and peripheral lymphoid organs Lymphocyte recirculation

13. IMMUNITY INNATE (Natural) (Native) ADAPTIVE (Aquired)

14. Principle mechanisms of innate and adaptive immunity

15. Principle mechanisms of innate and adaptive immunity

16. The most important cells of the immune system

17. Chain of events in infection

18. Pathogen(s) enter(s) tissue

21. Macrophages recognize (and eliminate) pathogens

24. Inflammation is induced and PMNs attracted

26. Antigen-presenting cells (APCs) capture antigen(s)

28. APCs migrate to draining lymph node

37. T cells are activated by APCs

40. B cell are activated (helped by T cells)

43. Activated B cells (plasma cells) produce antibodies (Abs)

47. Activated T cells and Abs leave lymph node...

48. ... enter blood stream and...

50. ... migrate to site of infection

53. Activated T cells stimulate phagocytes

57. Abs neutralize pathogens and stimulate phagocytes

62. http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf Pathogen is eliminated

63. Principle mechanisms of innate and adaptive immunity

64. Mechanisms of adaptive immunity - acquired throughout a lifetime of an individual - result of previous contact with pathogen - present in vertebrates

65. Properties of adaptive immunity - diversity and specificity - memory - clonal expansion - autotolerance - specialization - stimulation of mechanisms of innate immunity

66. Types of adaptive immunity

67. Phases of adaptive immune response

68. Types of lymphocytes

69. Lymphoid organs

70. Lymph node structure

72. Recirculation of T lymphocytes

73. The morphology of the spleen

75. Introduction to immune system Innate and adaptive immunity Types of adaptive immunity Properties and phases of adaptive immune response Central and peripheral lymphoid organs Lymphocyte recirculation

76. lymph nodes, spleen and MALTj.Primary adaptive immune response begins in 10. peripheral lymphoid organsi.Human peripheral (secondary) lymphoid organs are 9. epithelial barriersh.Human central (primary) lymphoid organs are 8. early defence against infectious agents g.Important properties of adaptive immune cells are 7. bone marrow and thymusf.Types of adaptive immunity are6. diversity, specificity and memorye.Cells of adaptive immunity are5. natural or native immunityd.Cells of innate immunity are4. B and T lymphocytesc.First line of defence of innate immunity is provided by 3. humoral and cellular immunity b. Mechanisms of innate immunity mediate 2. phagocytes and NK cellsa.Innate immunity is also called1. 1._____2._____3._____4._____5._____6._____7._____8._____9._____10.____ d.g.h.a.c.b.e.f.j.i.