1. Highlights of Immune System

2. Topic Outline Overview of the Immune System 1 st and 2 nd lines of Defense The Immune System  B cells  The antibody & antibody diversity  Vaccinations  Breast Feeding  Diagnostic applications  T cells  Allergies

3. Lines of Defense Physical and Chemical Immune system 3 rd line 1 st and 2 nd lines

4. First line of defense

5. Second line of defense  Inflammation  Phagocytic cells  complement

6. 3 rd line of defense “The Immune System”

7. Summary Lines of Defense INNATE ACQUIRED

8. Immune System B cells T cells

10. Lymph nodes are contain high concentrations lymphocytes

11. Let’s look more closely at the B lymphocytes

12. B Cell: humoral or antibody mediated immunity ANTIBODIES=IMMUNOGLOBULINS Humoral Immunity  Matures in bone marrow  Moves to lymph nodes (& other locations)  Secretes antibodies “as plasma cell”  Also creates “memory” B cells B-lymphocyte

13. CLONAL SELECTION

14. Different classes of immunoglobulins or antibodies IgM IgG IgA IgD IgE

15. Antibody Diversity

16. Antibody genes are composed of segments V J C

17. Somatic Recombination http://www.bio.davidson.edu/courses/Imm unology/Flash/somaticrecomb.html http://www.bio.davidson.edu/courses/Imm unology/Flash/somaticrecomb.html

18. How are vaccinations related to immunity? Active and Passive

19. Active Vaccinations: Antibody Production Memory Cells!

20. Immune Benefits of Breast Feeding IgA’s

21. The next part gets tricky Onto T Cells

22. All T cells require cell to cell contact

24. http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter24/animation__cytotoxic_t-cell_activity_against_target_cells__quiz_2_.html CD8+ CD4+ MHC=major histocompatibility complex: gene found on chromosome 6

25. Tissue Transplantation MHC proteins differ between individuals

26. Helper T Cell and MHC II Antigen presentation

27. Cytotoxic T Cell and MHC I Antigen presentation CD8+ cell

28. Cytotoxic T cell= CD8+

29. B lymphocytes source of antibodies Overview of T lymphocytes

30. Cancer cell being attacked by cytotoxic T cells After release of perforin

32. Allergies B cell also directly stimulated IgE