1. Cell-mediated immune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation

8. TCR TCR complex Molecules involved in T cell activation Costimulators

9. Requirement for two signals in T cell activation

11. Molecules involved in T cell activation Adhesion molecule Coreceptor

12. Molecules involved in T cell activation Accessory molecules

13. Molecules involved in T cell activation Immunological synapse

14. Biochemical pathways of T cell activation

15. Clustering of two or more TCRs

16. Functional responses of T lymphocytes to antigens and costimulation

18. Clonal expansion of T-limphocytes

21. Treg Naivna CD4 + T Naïve CD4 + T Th1 Th2 TGF-  TGF-  +IL-6 IL-4 IL-12+IL-18 IFN-  IL-23… Th17 Diferentiation od CD4 + T-limphocytes

22. Th17 Th1 Treg Naivna CD4 + T Th2 TGF-  TGF-  +IL-6 IL-4 IL-12+IL-18 IL-23… T-bet GATA-3 ROR  t FoxP3 IFN-  Th17 Diferentiation od CD4 + T-limphocytes Naïve CD4 + T

23. Diferentiation of naive CD4 + T-cells

24. Diferentiation od CD8 + T-limphocytes

26. CD3 complex and  chains j.Main transcription factors in T cell activation are10. T cell is not activatedi.Cytokine that is crucial for T H 1 differentiation is9. IL-12h.Activation of naive T-cells requires8. CD3, CD4, CD8, CD28 and adhesion molecules g. Adhesion molecules7. CD28 and B7 moleculesf. If APC does not express costimulatory molecules 6. NFAT, NF-  B and AP1 e. T cell growth factor is5. two signalsd. Costimulatory signals for T cell activation are provided by 4.  and  chains of TCR c. Accesory molecules involved in T cell activation are 3. stabilize binding of T-cells to APC b. Signal transduction in T cells is mediated by2. IL-2a.Recognition of antigen by T cells is mediated by1. 10.____9.____8.____7.____6.____5.____4.____3.____2.____1.____ cjgfaibdhe