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Published byGertrude Bridges Modified over 9 years ago
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التصنيف العام للفيروسات Classification Lowff 1962 Bacteria, Plant, Animal Phylum, Class, Order, Family, Genus, Species International committee on Taxonomy of Viruses ICTV مميزات الفيروس نوع الحامض النووي
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Classification 1. The classical system of classification: DNA+ RNA Symmetry of the capsid Envelope (+) or (-) Virion diameter
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Human herpesvirus 8 subfamily: Gammaherpesvirinae DNA-sequence HCV - Flaviviridae cloned-DNA
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II- The Baltimore classification: “ Central Dogma” DNA mRNA Protein I. (+&-) DNA (+) mRNA II. (+) DNA (+&-) DNA III (+&-) RNA (+) mRNA IV (+) RNA (-) RNA V (-) RNA (+) mRNA VI (+) RNA (-) DNA
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تصنيف بالتيمور Baltimore classification DNA mRNAProtein (+) strand RNA mRNA DNA mRNA + -
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ATG GGGCCC, DNA,RNA TACCCC GGG,, DNA,RNA AUGGGGCCCmRNA UACCCCGGGmRNA + + - -
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ATG GGG CCC GGG (+), (-), DNA, RNA TAC CCC GGG CCC (+), (-), DNA, RNA AUG GGG CCC GGG mRNA OR UAC CCC GGG CCC mRNA
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ATG GGG CCC GGG (+), DNA TAC CCC GGG CCC (-), DNA AUG GGG CCC GGG mRNA
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ATG GGG CCC GGG (-), DNA TAC CCC GGG CCC (+), DNA UAC CCC GGG CCC mRNA
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II- The Baltimore classification: “Central Dogma” DNA mRNA Protein I. (+&-) DNA (+) mRNA II. (+) DNA (+&-) DNA III (+&-) RNA (+) mRNA IV (+) RNA (-) RNA V (-) RNA (+) mRNA VI (+) RNA (-) DNA
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تصنيف وتسمية الفيروسات Taxonomy and Nomenclature of viruses Family/ عوائل NA, Size, Shape, structure, Type replication Genera / Species Antigenicity Base sequence homology (Protein or NA)
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ICTV Order – Family – Subfamily – Genus – Strain / Type Suffix: Order: Virales Family: Viridae SubFamily: Virinae Genus: Virus Species: I.V.
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مثال Example : Poxviridae Herpesviridae Picornaviridae Paramyxoviridae Mononegavirales - Order Paramyxoviridae - Family Paramyxovirinae - Subfamily Morbillivirus - Genus Measles virus - Species
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ICTV > 4000 Viruses Plant, Bacteria, Animal, Human …….ect 71 Family عائلة 71 Family عائلة 9 Subfamily تحت عائلة 9 Subfamily تحت عائلة 164 Genera جنس 164 Genera جنس 300 Viruses - human 50 Syndrome
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زراعة الفيروسات Cultivation of viruses 1.Tissue culture المزارع الخلوية 2. Chick embryo أجنة الدجاج 3. Lab animal حيوان تجارب Pathogenesis and oncogensis
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أنواع المزارع الخلوية Type of cell culture John Enders -1949 Noble prize / physiology 1954 PoliovirusT.C. T.C.New virus Vaccines Poliomyelitis, measles, Rubella
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المزارع الخلوية الأولية Primary Cell Culture انقسامات 10 - 5 خلايا / القر و د ، الإنسان ، الفئران …… الخ * Vaccine Poliomyelitis شلل الأطفال Primary monekey kidney cells Live attenuated poliovirus vaccine * Not oncogenic DNA
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- 100 إنقسام Vaccine: WI-38 Rabies - Inactivated vaccine المزارع الثانوية Secondary Cell Culture Diploid cell strain خلايا شبه مستمرة Semi continuous cells
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المزارع الخلوية - المستمرة Continuous Cell line Immortal line Cells Rx - tumor virus - carcinogenic Reagent Aneuploid ex -Hep-2, Hela cells- Human - Vero cells- monkey - L and 3T3 cells - Mice - BHK cells - Hamster Tumor tissue
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الخلايا اللمفاوية Lymphocytes culture B- lymphocytes EBV T: Transformation, immortalization T- lymphocytesIL-2 المزارع المعلقة Suspension culture - Large number of cells X-ray crystallography T
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أجنة البيض Embryonated eggs 5-14 / يوم Vaccine Iafluenza Virus Measles حيوانات التجارب Laboratory animals -mutation تطفر Poliovirus oral- route Needed For: HCV- chimpanzee Norwalk virus Human Gastrointritis
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