1. Genes and Function: The Rewriting of our Textbooks of Pathology Presented By David Hafler at 2014 ASCO Annual Meeting

2. Slide 2 Presented By David Hafler at 2014 ASCO Annual Meeting

3. Slide 3 Presented By David Hafler at 2014 ASCO Annual Meeting

4. Slide 4 Presented By David Hafler at 2014 ASCO Annual Meeting

5. Slide 5 Presented By David Hafler at 2014 ASCO Annual Meeting

6. Slide 6 Presented By David Hafler at 2014 ASCO Annual Meeting

7. Slide 7 Presented By David Hafler at 2014 ASCO Annual Meeting

8. Slide 8 Presented By David Hafler at 2014 ASCO Annual Meeting

9. Slide 9 Presented By David Hafler at 2014 ASCO Annual Meeting

10. Slide 10 Presented By David Hafler at 2014 ASCO Annual Meeting

11. Slide 11 Presented By David Hafler at 2014 ASCO Annual Meeting

12. Slide 12 Presented By David Hafler at 2014 ASCO Annual Meeting

13. Slide 13 Presented By David Hafler at 2014 ASCO Annual Meeting

14. Slide 14 Presented By David Hafler at 2014 ASCO Annual Meeting

15. Slide 15 Presented By David Hafler at 2014 ASCO Annual Meeting

16. Glioblastoma multiforme Presented By David Hafler at 2014 ASCO Annual Meeting

17. Treatments Presented By David Hafler at 2014 ASCO Annual Meeting

18. WHO Classification Presented By David Hafler at 2014 ASCO Annual Meeting

19. Slide 19 Presented By David Hafler at 2014 ASCO Annual Meeting

20. Slide 20 Presented By David Hafler at 2014 ASCO Annual Meeting

21. PD-1 Expression CD4 T effectors in on Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

22. Slide 22 Presented By David Hafler at 2014 ASCO Annual Meeting

23. Slide 23 Presented By David Hafler at 2014 ASCO Annual Meeting

24. Slide 24 Presented By David Hafler at 2014 ASCO Annual Meeting

25. Slide 25 Presented By David Hafler at 2014 ASCO Annual Meeting

26. Patient survival linked to Tumor-associated Tregs Presented By David Hafler at 2014 ASCO Annual Meeting

27. Increase numbers of regulatory T Cells in Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

28. Tregs and CD4 T effector cells in glioblastoma are Tim3+PD-1+ Presented By David Hafler at 2014 ASCO Annual Meeting

29. Slide 29 Presented By David Hafler at 2014 ASCO Annual Meeting

30. PD-1+Tim3+ Tregs restricted to grade 4 glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

31. Absence of Tim3+PD-1+ Tregs in the blood of healthy controls Presented By David Hafler at 2014 ASCO Annual Meeting

32. Slide 32 Presented By David Hafler at 2014 ASCO Annual Meeting

33. Slide 33 Presented By David Hafler at 2014 ASCO Annual Meeting

34. Slide 34 Presented By David Hafler at 2014 ASCO Annual Meeting

35. Slide 35 Presented By David Hafler at 2014 ASCO Annual Meeting

36. Blocking monoclonal antibodies increase CD4 T effector proliferation but not Treg suppression Presented By David Hafler at 2014 ASCO Annual Meeting

37. Slide 37 Presented By David Hafler at 2014 ASCO Annual Meeting

38. Impaired suppression by GBM-Treg and proliferative response by GBM-Teff Presented By David Hafler at 2014 ASCO Annual Meeting

39. PD-1+Tim3+ Tregs have decreased suppressor function Presented By David Hafler at 2014 ASCO Annual Meeting

40. PD-1+ CD4 effector cells and Tregs have shortened telomeres Presented By David Hafler at 2014 ASCO Annual Meeting

41. Slide 41 Presented By David Hafler at 2014 ASCO Annual Meeting

42. Slide 42 Presented By David Hafler at 2014 ASCO Annual Meeting

43. Slide 43 Presented By David Hafler at 2014 ASCO Annual Meeting