1. “Reversing MetS (Metabolic Syndrome) with MSRP (Metabolic Syndrome Reversal Program) Through Integrative Whole Food Dietary Recommendations and Sprint Interval Training” Oscar Coetzee, Dr. Barry S. Kendler Oscar Coetzee, Dr. Barry S. Kendler Nutrition Institute Nutrition Institute University of Bridgeport, Bridgeport, CT The MSRP provides this and also the following: Proper effective exercise program, that has health benefits Is not too time consuming and can be completed by all ages Proper dietary protocols that have enough variety and choices that people can make permanent lifestyle adjustments by incorporating them after leaving the program. Proper “recovery” protocols so that when a person goes off the MSRP, they can get back on track for future maintenance Table 1 (Overall) Lab Testn = 73Mean PreMean PostPt. +/-% Change Triglycerides73163.599.6-63.9-39.1% LDL73143.8110.1-33.7-23.4% HDL7355.854.2-1.7-0.03% Total Cholesterol73226.8183.6-43.3-19.1% Weight73203.3177.8-25.5-12.6% Lab Testn= /73 Mean Pre Mean PostPt. +/-% Change Ref. RangeReversalReversal% Triglycerides36235.7121.0-114.7-48.7%<1502949.3% LDL49163.6119.3-44.3-27.1%<1303163.3% HDL2238.142.03.910.3%>40m/50f418.2% Total Cholesterol57242.7191.5-51.3-21.1%<2003478.1% BMI4035.230.9-4.3-12.2%<30820.5% Table 2 (Subset) Triglycerides overall (n=73) were reduced by 39.1%, and in the subset group (n=36) by 48.7%, with an overall reversal to optimal levels of 49.3%. Thus, 29/36 lowered their values to optimal ranges (<150mg/dl). LDL overall (n=73) was reduced by 23.4% and in the subset group (n=49) by 27.1%, with an overall reversal to optimal levels of 63.3%. Thus, 31/49 individuals lowered their values to optimal ranges(<130mg/dl). HDL overall (n=73) was reduced by 0.03% (thus no clear positive change) and in the subset group HDL (n=22) there was an increase of 10.3% (positive increase), with an overall increase to optimal ranges of 18.2%. Thus, 4/22 individuals reached optimal reference range status (F > 50mg/dl, M > 40mg/dl). Total cholesterol overall (n=73) was reduced by 19.1% and in the subset group (n=57) by 21.1%, with 78.1% decreased to optimal levels. Thus, 34/57 no longer were in MetS inclusion criteria (> 200mg/dl). BMI in the subset group was reduced by 12.2% (n=40), with a reversal of BMI to optimal (<30 kg/m2) at 20.5%. Overall weight loss did not need to be put into a subset group as weight is not a direct inclusion criterion. However (n=73) had an original mean weight of 203.3 lbs and a final mean weight of 177.8 lbs. Thus, they experienced an average weight loss of 25.5 lbs or 12.6% reduction in weight in 12 weeks. Objective: Objective: To determine the level of reversal of Metabolic Syndrome (MetS) and blood chemistry changes among clients following an integrated lifestyle change 12 week program called MSRP. The motivations in designing the MSRP program were two: completely reverse MetS and to maintain reversal of the condition. Study Design: A case series of clients with metabolic syndrome that were put on a specific dietary and exercise program for 12 weeks is described. Participation in this program was determined through the inclusion criteria of the MSRP (Metabolic Syndrome Reversal Program) and the diagnosis of MetS through a licensed Health Care Provider. The study was done through a chart review of 73 clients age 30 -81 observed between August 2010 and October 2011. Results: The mean age of the clients in this series was 55.5, 28 of whom were male (38.4%) and 45 were female (61.6%). The subjects included 57 (78.1%) clients whose serum cholesterol was above the normal (>200mg/dL) range and 36 (49.3%) clients had elevated (>150mg/dL) serum triglyceride. There were 49 (67.1%) clients whose LDL cholesterol was above (>130) and 22 (30.1%) had below average HDL ( 30 kg/m² and were thus clinically defined as obese. Result Charts Introduction: Metabolic Syndrome (MetS) is a combination of risk factors and progressive metabolic changes in the body that could lead to cardiovascular disease and diabetes [1][2][3][4]. In this trial MetS was investigated to see if the Metabolic Syndrome Reversal Program (MSRP) could show clinically meaningful statistical significance in reversing the condition as a whole and improving the blood chemistry of the subjects. The MSRP resulted in significantly favorable changes in the overall MetS criteria and blood chemistry following the completion of the 12 week program. The subset group exhibited a significant reversal in criteria for MetS classification. Accordingly, the program was considered to be successful. Methodology: This study involves a case series of patients with MetS diagnosed by a licensed Healthcare provider at the MSRP Health Centers (California and New Jersey). The study was conducted through a chart review of 73 selected patients aged 30 years old and above with a diagnosis of MetS, that were seen over a one year period between August 2010 to September 2011 at the MSRP Health Centers. Measurements were done at baseline and 12 weeks. Strict MSRP Dietary protocols were followed for the 12 weeks [5][6][7][8] and a three times per week Sprint Interval Training (SIT) [9] exercise program. Compliance was measured through weekly follow ups, questionnaires and evaluations by MSRP Life Style Educators and clinical nutritionists. Statistical Data Conclusion References: [1] Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome a new worldwide definition. Lancet 2005; 366:1059-62. [2] Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant D, for the Conference Participants. Definition of metabolic syndrome: report of the National, Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433-438. [3] Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Jr, Spertus JA Costa F. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735-2752. [4] World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation 1999. [5] http://naturalhealthcarecenter.com/docs/GlycemicIndexProtocol.pdf [6] http://naturalhealthcarecenter.com/docs/Integrated21DProtocol.pdf [7]http://naturalhealthcarecenter.com/docs/PaleolithicProtocolForAthletes. pdf [8] http://naturalhealthcarecenter.com/docs/ComboMaintProtocol.pdf [9] Smith, MJ. Sprint Interval Training – It’s a “HIIT” A research paper discussing the superior health and performance benefits of high-intensity intermittent exercise over low to moderate-intensity continuous exercise. 2nd edition, 2008: (1-45).