1. Ebola Virus Nicole Fossas Biology 402

2. Causative Agent 1.Zaire 2.Sudan 3. Bundibugyo 4. Reston 5. Ivory Coast

3. Challenges in Studying Ebola

4. World Distribution- Outbreaks

5. Signs and Symptoms fever, muscle pain, sore throat, headache, vomiting, diarrhea it’s easily misdiagnosed characterized later by damage to blood vessels and internal and external bleeding Fatality rate of up to 90% (ranges from 50- 90%)

6. Transmission Contact with the virus from dead or infected people or wildlife – Skin abrasions – Contaminated needles – Mucosal surfaces

7. Outbreaks since 2000 (Data from May 2012)

8. Ebola virus and the genes it encodes for

9. Structure of the virus, including the surface proteins thought to be important to infect

10. Host Immune Response

11. Outbreaks only in Africa– suggest natural reservoir is there

12. References “Ebola”, NIH. http://www.ncbi.nlm.nih.gov/pubmed/23327370http://www.ncbi.nlm.nih.gov/pubmed/23327370 “Ebola Virus”, Baylor College of Medicine. https://www.bcm.edu/departments/molecular-virology-and- microbiology/ebola https://www.bcm.edu/departments/molecular-virology-and- microbiology/ebola “Viral Hemorrhagic Fevers”, CDC. http://www.cdc.gov/vhf/ebola/http://www.cdc.gov/vhf/ebola/ “Ebola Hemorrhagic Fever”, Medicine Plus. http://www.nlm.nih.gov/medlineplus/ency/article/001339.htm http://www.nlm.nih.gov/medlineplus/ency/article/001339.htm “Ebola Hemorrhagic Fever”, Infection Landscapes. http://www.infectionlandscapes.org/2012/11/ebola-hemorrhagic-fever.html http://www.infectionlandscapes.org/2012/11/ebola-hemorrhagic-fever.html Lee, J., Saphire, E. “Ebolavirus glycoprotein structure and mechanism of entry.” Future Virology. 4.6 (2009) pp. 621-35. Sullivan, N., Yang, Z., and Nabel, G. “Ebola Virus Pathogenesis: Implications for Vaccines and Therapies.” Journal of Virology. 77.18 (2003) pp. 9733-37.