1. Cellular Respiration Chapter 7 Table of Contents Section 1 Glycolysis and Fermentation Section 2 Aerobic Respiration

2. Section 1 Glycolysis and Fermentation Chapter 7 Objectives Identify the two major steps of cellular respiration. Describe the major events in glycolysis. Compare lactic acid fermentation with alcoholic fermentation. Calculate the efficiency of glycolysis.

3. Chapter 7 Harvesting Chemical Energy Cellular respiration is the process by which cells break down organic compounds to produce ATP. Both autotrophs and heterotrophs use cellular respiration to make CO 2 and water from organic compounds and O 2. The products of cellular respiration are the reactants in photosynthesis; conversely, the products of photosynthesis are reactants in cellular respiration. Cellular respiration can be divided into two stages: glycolysis and aerobic respiration. Section 1 Glycolysis and Fermentation

4. Chapter 7 Photosynthesis-Cellular Respiration Cycle Section 1 Glycolysis and Fermentation

5. Chapter 7 Glycolysis Cellular respiration begins with glycolysis, which takes place in the cytosol of cells. During glycolysis, one six-carbon glucose molecule is oxidized to form two three-carbon pyruvic acid molecules. A net yield of two ATP molecules is produced for every molecule of glucose that undergoes glycolysis. Section 1 Glycolysis and Fermentation

6. Chapter 7 Glycolysis Section 1 Glycolysis and Fermentation

7. Chapter 7 Fermentation If oxygen is not present, some cells can convert pyruvic acid into other compounds through additional biochemical pathways that occur in the cytosol. The combination of glycolysis and these additional pathways is fermentation. Fermentation does not produce ATP, but it does regenerate NAD +, which allows for the continued production of ATP through glycolysis. Section 1 Glycolysis and Fermentation

8. Chapter 7 Cellular Respiration Versus Fermentation Section 1 Glycolysis and Fermentation

9. Chapter 7 Fermentation, continued Lactic Acid Fermentation –In lactic acid fermentation, an enzyme converts pyruvic acid into another three-carbon compound, called lactic acid. Section 1 Glycolysis and Fermentation

10. Chapter 7 Fermentation, continued Alcoholic Fermentation –Some plants and unicellular organisms, such as yeast, use a process called alcoholic fermentation to convert pyruvic acid into ethyl alcohol and CO 2. Section 1 Glycolysis and Fermentation

11. Chapter 7 Two Types of Fermentation Section 1 Glycolysis and Fermentation

12. Chapter 7 Fermentation, continued Through glycolysis, only about 2 percent of the energy available from the oxidation of glucose is captured as ATP. Much of the energy originally contained in glucose is still held in pyruvic acid. Glycolysis alone or as part of fermentation is not very efficient at transferring energy from glucose to ATP. Section 1 Glycolysis and Fermentation

13. Section 2 Aerobic Respiration Chapter 7 Overview of Aerobic Respiration In eukaryotic cells, the processes of aerobic respiration occur in the mitochondria. Aerobic respiration only occurs if oxygen is present in the cell. The Krebs cycle occurs in the mitochondrial matrix. The electron transport chain (which is associated with chemiosmosis) is located in the inner membrane.

14. Section 2 Aerobic Respiration Chapter 7 The Krebs Cycle In the mitochondrial matrix, pyruvic acid produced in glycolysis reacts with coenzyme A to form acetyl CoA. Then, acetyl CoA enters the Krebs cycle. One glucose molecule is completely broken down in two turns of the Krebs cycle. These two turns produce four CO 2 molecules, two ATP molecules, and hydrogen atoms that are used to make six NADH and two FADH 2 molecules. The bulk of the energy released by the oxidation of glucose still has not been transferred to ATP.

15. Section 2 Aerobic Respiration Chapter 7 Electron Transport Chain and Chemiosmosis High-energy electrons in hydrogen atoms from NADH and FADH 2 are passed from molecule to molecule in the electron transport chain along the inner mitochondrial membrane.

16. Section 2 Aerobic Respiration Chapter 7 Electron Transport Chain and Chemiosmosis, continued Protons (hydrogen ions, H + ) are also given up by NADH and FADH 2. As the electrons move through the electron transport chain, they lose energy. This energy is used to pump protons from the matrix into the space between the inner and outer mitochondrial membranes. The resulting high concentration of protons creates a concentration gradient of protons and a charge gradient across the inner membrane.

17. Section 2 Aerobic Respiration Chapter 7 Electron Transport Chain and Chemiosmosis, continued As protons move through ATP synthase and down their concentration and electrical gradients, ATP is produced. Oxygen combines with the electrons and protons to form water.

18. Section 2 Aerobic Respiration Chapter 7 Electron Transport Chain and Chemiosmosis, continued The Importance of Oxygen –ATP can be synthesized by chemiosmosis only if electrons continue to move along the electron transport chain. –By accepting electrons from the last molecule in the electron transport chain, oxygen allows additional electrons to pass along the chain. –As a result, ATP can continue to be made through chemiosmosis.

19. Section 2 Aerobic Respiration Chapter 7 Efficiency of Cellular Respiration Cellular respiration can produce up to 38 ATP molecules from the oxidation of a single molecule of glucose. Most eukaryotic cells produce about 36 ATP molecules per molecule of glucose. Thus, cellular respiration is nearly 20 times more efficient than glycolysis alone.

20. Section 2 Aerobic Respiration Chapter 7 A Summary of Cellular Respiration Another Role of Cellular Respiration –Providingn cells with ATP is not the only important function of cellular respiration. –Molecules formed at different steps in glycolysis and the Krebs cycle are often used by cells to make compounds that are missing in food.

21. Chapter 7 Summary of Cellular Respiration Section 2 Aerobic Respiration