Presentation is loading. Please wait.

Presentation is loading. Please wait.

Is It Alzheimer’s? The Latest Update on Optimal Evaluation and Treatment of Patients with Memory Loss Majid Fotuhi, MD PhD March 5, 2014.

Published byOctavia McCormick Modified over 9 years ago

Similar presentations

Presentation on theme: "Is It Alzheimer’s? The Latest Update on Optimal Evaluation and Treatment of Patients with Memory Loss Majid Fotuhi, MD PhD March 5, 2014."— Presentation transcript:

1 Is It Alzheimer’s? The Latest Update on Optimal Evaluation and Treatment of Patients with Memory Loss Majid Fotuhi, MD PhD March 5, 2014

2 New Discoveries 2

3 65 year old woman with history of depression and OSA presents with memory loss and concern for Alzheimer’s disease  Was working full time until two years ago at SS, as a manager and program analyst  Husband had severe respiratory disease and she was taking care of him until three months ago, when he died  Family had noticed a progressive memory loss for approximately 1-2 years (since retirement)  Spends much of her time at home, with no social activities or interest in taking on new hobbies  Sister is convinced she has Alzheimer’s disease  Was referred to NeurExpand Brain Center for further evaluation and treatment  Is it Alzheimer’s? What can be done for her? 3

4 Immediate Memory Letter FluencySustained AttentionProcessing Speed Delayed Memory Baseline NeuroCognitive Assessments April 18, 2013 4

5 MoodAnxietyInsomnia Cognitive InhibitionCognitive flexibilityInhibition & flexibility Baseline NeuroCognitive Assessment April 18, 2013 5

6 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 6

7 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 7

8 MCI DEMENTIA 8

9 Memory Lapses Memory Lapses or Alzheimer’s? Age-Associated Memory Impairment MCI Alzheimer’s 9

10 Short-term: Hippocampus Long-term: Cortex Cortex Hippocampus 10

11 Beautiful Neurons in Hippocampus 11

12 Hippocampal Atrophy is the Most Robust Marker for Dementia Duara et al., Neurology 71:1986–92, 2008 12

13 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 13

14 Overlapping Causes of Atrophy in Hippocampus Obesity-Diabetes Stroke Sleep Apnea Concussion AD Inflammation Stress 14

15 Brain is a Highly Vascular Organ Zlokovic et al. Neurosurgery 43(4), 877–78, 1998 15

16 Vascular Brain Atrophy in OSA Am J Respir Crit Care Med 2002; 166:1382–7 16

17 Obesity Shrinks the Brain  Associated with reduced brain volume Ward, et al., 2005  Slows cognitive function Debette, et al., 2011  Brains of overweight and obese individuals appeared 8 and 16 years older, respectively Raji, et al., 2010 17 Brain Research Volume 1280, 14 July 2009, Pages 186–194

18 Figure 1 Comparison of studies of hippocampal volume in patients with cardiovascular disease Fotuhi, M. et al. (2012) Modifiable factors that alter the size of the hippocampus with ageing Nat. Rev. Neurol. doi:10.1038/nrneurol.2012.27 18

19 Multiple Vascular Risk Factors: Worse Atrophy in the Brain Multiple Vascular Risk Factors No Vascular Risk Factors Hippocampus 19

20 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 20

21 Treating Vascular Risk Factors Slows Decline in Dementia Deschaintre et al., Neurology 73:674–80, 2009 Deschaintre, 20093:674–80, 2009 21

22 Physical Activity and Mediterranean Diet, More Effective Together al., JAMA 302 (6):627–37, 2009 Scarmeas et al, 2009 22

23 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 23

24 6 Steps to Grow Your Brain 1. Get Fit 2. Tease Your Memory 3. Eat Well &Take DHA 4. Sleep 5. Relax Your Mind 6. Start Early 24

25 1. Hippocampus Grows Bigger with Getting Fit Erikson, PNAS 2011 25

26 Arch Gen Psychiatry, 2010 Hippocampus Grows Bigger with Exercise, Even After 3 Months After Before 26

27 More Exercise: More Brain Cells Van Praag, Trends in Neurosciences, 2009 27

28 Draganski et al. J Neurosci 2006; 26:6314–7 2. Hippocampus Grows Bigger with Memorization Training 28

29 3. Hippocampus Grows Bigger with Eating Well & Taking DHA 29

30 More DHA-EPA: Bigger Hippocampus 30 Pottala J V et al. Neurology 2014;82:435-442 30

31 Fotuhi et al., Nature Clinical Practice Neurology 5(3):140–52, 2009 31

32 32 4. Hippocampus Grows Bigger with Treatment of Sleep Apnea Canesa, American Journal of Respiratory Medicine, 2011

33 5. Hippocampus Grows Bigger with Relaxing Your Mind Holzel, Psychiatric Research, 2011 33

34 34 6. Hippocampus Grows Bigger When You Start Early

35 Figure 3 Pathways leading to hippocampal growth or atrophy Fotuhi, M. et al. (2012) Modifiable factors that alter the size of the hippocampus with ageing Nat. Rev. Neurol. doi:10.1038/nrneurol.2012.27

36 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our Brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 36

37 Brain Fitness Program  A multidisciplinary program devoted to: - Improving memory and brain performance - Enhancing long-term brain health - Reducing risk for dementia, Alzheimer’s disease and stroke in the future  Each patient receives a comprehensive baseline assessment followed by a personalized treatment plan  This program is based on latest research and has shown remarkable results 37

38 Comprehensive Diagnostics to Evaluate Brain Health Customized Treatment Program to Maximize Brain Performance NeurExpand’s Unique Integrative Approach 38

39 Neuro-feedback for Treatment of Depression 39

40 Immediate Memory Post Brain Fitness Program Follow-Up July 29, 2013 Letter FluencySustained AttentionProcessing Speed Delayed Memory 40

41 4/18/137/29/13 MoodAnxiety 4/18/137/29/134/18/137/29/13 Insomnia Cognitive InhibitionCognitive flexibilityInhibition & flexibility 41 Post Brain Fitness Program Follow-Up July 29, 2013

42 2.86 cm 3 3.14 cm 3 42 MRI Results Before After

43 Objectives  What is the difference between memory loss, MCI, and Alzheimer’s?  Why does the brain shrink with aging?  Can we reverse the effects of aging on the brain?  Can we grow the size of our brain?  Can we expand our cognitive performance and brain size? The Brain Fitness Program 43

44 THANK YOU! MFotuhi@NeurExpand.com 44

45 Baseline MRI… 45

Download ppt "Is It Alzheimer’s? The Latest Update on Optimal Evaluation and Treatment of Patients with Memory Loss Majid Fotuhi, MD PhD March 5, 2014."

Similar presentations

APOE Genotype Effects on Alzheimer’s Disease Clinical Onset, Epidemiology, and Gompertzian Aging Functions J.Wesson Ashford, M.D., Ph.D. Stanford / VA.

APOE Genotype Effects on Alzheimer’s Disease Clinical Onset, Epidemiology, and Gompertzian Aging Functions J.Wesson Ashford, M.D., Ph.D. Stanford / VA.
Speed of processing, the missing measure in early detection of MCI? Ruth O’Hara March 13 th 2001 Yogesh Shah.

Speed of processing, the missing measure in early detection of MCI? Ruth O’Hara March 13 th 2001 Yogesh Shah.
Frontotemporal Dementia

Frontotemporal Dementia
The New Brief Cognitive Assessment Tool (BCAT): The Role of Cognitive Assessment in Improving Health Outcomes Dr. William Mansbach October 25, 2011.

The New Brief Cognitive Assessment Tool (BCAT): The Role of Cognitive Assessment in Improving Health Outcomes Dr. William Mansbach October 25, 2011.
Mild Cognitive Impairment as a Target for Drug Development Steven H. Ferris, Ph.D. Silberstein Aging and Dementia Research Center New York University School.

Mild Cognitive Impairment as a Target for Drug Development Steven H. Ferris, Ph.D. Silberstein Aging and Dementia Research Center New York University School.
MCI Clinical Trial Design FDA Advisory Committee Meeting March 13, 2001 Gaithersburg, MD Michael Grundman, MD, MPH Alzheimer’s Disease Cooperative Study.

MCI Clinical Trial Design FDA Advisory Committee Meeting March 13, 2001 Gaithersburg, MD Michael Grundman, MD, MPH Alzheimer’s Disease Cooperative Study.
Raghu Upender, MD Assistant Professor in Neurology Medical Director Vanderbilt Sleep Disorders Center.

Raghu Upender, MD Assistant Professor in Neurology Medical Director Vanderbilt Sleep Disorders Center.
Dementia. Definition Loss of function in multiple cognitive abilities Assuming the individual had normal abilities before the onset Many of the 70 recognized.

Dementia. Definition Loss of function in multiple cognitive abilities Assuming the individual had normal abilities before the onset Many of the 70 recognized.
Indianapolis Discovery Network for Dementia Translating PREVENT Into Your Practice Caring for your patients with dementia J. Eugene Lammers, MD, MPH Clarian.

Indianapolis Discovery Network for Dementia Translating PREVENT Into Your Practice Caring for your patients with dementia J. Eugene Lammers, MD, MPH Clarian.
Dementia in People with a Learning Disability A Care Pathway Using a Collaborative Approach ANDREW GRIFFITHS.

Dementia in People with a Learning Disability A Care Pathway Using a Collaborative Approach ANDREW GRIFFITHS.
Alzheimer’s Disease and Biomarkers John H. Dougherty,Jr.M.D. Medical Director Cole Neuroscience Center.

Alzheimer’s Disease and Biomarkers John H. Dougherty,Jr.M.D. Medical Director Cole Neuroscience Center.
ADRC Training1 Meeting the Needs of Aging Persons with Developmental Disabilities Cross Network Collaboration for Florida Bridging the Networks - Needs.

ADRC Training1 Meeting the Needs of Aging Persons with Developmental Disabilities Cross Network Collaboration for Florida Bridging the Networks - Needs.
Dementia Research Group MRI, rates of atrophy and Alzheimer’s disease Nick Fox Dementia Research Group Institute of Neurology, UCL Queen Square, London.

Dementia Research Group MRI, rates of atrophy and Alzheimer’s disease Nick Fox Dementia Research Group Institute of Neurology, UCL Queen Square, London.
THINKING ABOUT MIND AND BRAIN  “Mind” “Brain activity”  APA (2000) the word “Mental” in patients title perpetuates the idea that mental and physical.

THINKING ABOUT MIND AND BRAIN  “Mind” “Brain activity”  APA (2000) the word “Mental” in patients title perpetuates the idea that mental and physical.
Cognitive Development in late Adulthood Chapter 18 © 2013 by McGraw-Hill Education. This is proprietary material solely for authorized instructor use.

Cognitive Development in late Adulthood Chapter 18 © 2013 by McGraw-Hill Education. This is proprietary material solely for authorized instructor use.
Late Adulthood Longevity The course of physical development Health Cognitive functioning Memory Work and retirement Mental health Religion Theories of.

Late Adulthood Longevity The course of physical development Health Cognitive functioning Memory Work and retirement Mental health Religion Theories of.
Decision presented by the committee board members: Nicholas Mann & Katelyn Strasser FUTURE FUNDING FOR ALZHEIMER’S DISEASE October 14, 2014 MPH 543 Leadership.

Decision presented by the committee board members: Nicholas Mann & Katelyn Strasser FUTURE FUNDING FOR ALZHEIMER’S DISEASE October 14, 2014 MPH 543 Leadership.
Exercise and the Brain Majid Fotuhi, MD PhD Baltimore Psychological Assoc. March 15, 2015.

Exercise and the Brain Majid Fotuhi, MD PhD Baltimore Psychological Assoc. March 15, 2015.
Mild Cognitive Impairment

Mild Cognitive Impairment
How To Improve Memory Performance and Keep Your Brain Young Gary W. Small, MD Parlow-Solomon Professor on Aging Professor of Psychiatry & Biobehavioral.

How To Improve Memory Performance and Keep Your Brain Young Gary W. Small, MD Parlow-Solomon Professor on Aging Professor of Psychiatry & Biobehavioral.

Similar presentations

Ads by Google