1. Home delivery – Clotting Factors Edinburgh – 4 th January 2007 Dominic Moreland – Managing Director, Careology Mandy Wakefield – Director of Nursing, Careology Claire Willits - Special Projects Manager, Polar Speed

2. Partnership Ethos To provide exceptional standards of medical care to patients receiving therapy for complex disorders in their own homes. This is achieved through the maintenance of a specialist team who are well trained and experienced and who focus on specific therapeutic areas. The service is flexible and tailored to the needs of the customer and patient.

3. Careology and Polar Speed Partnership Formed from MBO of Genzyme Homecare Specialist integrated homecare service provider with extensive experience of dealing with rare genetic disorders Established 1996 Specialist Pharmaceutical Cold chain distributor including Haemophilia Treatment products Established industry customer base Management team experience in pharmaceutical industry and homecare

4. Patient Journey Registration Prophylaxis or On Demand therapy Consent System set up Prescription Generated Buffer Stock consideration Home deliveries Scheduled Patient Management Prescription Management Coordinator Contact Pharmaceutical Deliveries Clinical Waste Clinical Feedback KPI reporting Service Survey Main Centre Referral

5. Communication * Driver endorses for key holder service Communication Registration Patient Monitoring and Clinical Governance - Triggers Service Reviews Invoicing Management Reports Homecare Deliveries Coordinator telephone calls Patient Monitoring Service Quality surveys Clinical Review Service Feedback

6. Home Delivery Arrangements Drivers have been through an enhanced CRB check and have disease awareness training Cold chain validation within MHRA, RPSGB and ISO 9001:2000 requirements Vehicles with company logo and uniformed driver with ID Three hour time delivery window Deliveries made between 08.00 and 18.00 and at other times on request Flexibility for on demand or prophylaxis patients and emergency deliveries Sharps Bin Removal and environmental disposable including packaging Key Holding Service

7. Home Delivery Value adds Polar Track and Refrigerated Van deliveries – no need for validated packaging for routine deliveries Stock Rotation and expiry date checking Clinical Feedback through patient monitoring Patient satisfaction surveys Signed Proof of delivery with Invoice Alternative / additional delivery address

8. Polar Track Online Track & Trace Online Temperature Monitoring Online Proof of Delivery Online Service Level / Performance Reporting Online Collection Request Online Automated Routing

10. Summary Patient focused and flexible to customer needs Collaborative working emphasis Service aids compliance and patient monitoring in line with Haemophilia Team goals and objectives Clinical Governance and audit strong priority Direct operational responsibility of owner managers