1. Biosystems Task Force Goals Goals Members Members FOSBE FOSBE Teaching Modules Teaching Modules Spring Trustees Meeting Itasca, IL 14 June 2013

2. Task Force Goals Develop educational materials for the undergraduate ChE curriculum Develop educational materials for the undergraduate ChE curriculum Provide training opportunities for graduate students interested in biological systems research Provide training opportunities for graduate students interested in biological systems research Offer the Foundations of Systems Biology in Engineering (FOSBE) conference series Offer the Foundations of Systems Biology in Engineering (FOSBE) conference series Increase the visibility of biosystems in ChE education Increase the visibility of biosystems in ChE education

3. Task Force Members Wayne Bequette (RPI, Chair) Wayne Bequette (RPI, Chair) Mike Henson (UMass, Co-chair) Mike Henson (UMass, Co-chair) Frank Doyle (UCSB) Frank Doyle (UCSB) Marianthi Ierapetritou (Rutgers) Marianthi Ierapetritou (Rutgers) David Balaban (Amgen) David Balaban (Amgen) Vassily Hatzimanikatis (EPFL) Vassily Hatzimanikatis (EPFL) Juergen Hahn (RPI) Juergen Hahn (RPI) Claire Komives (San Jose State) Claire Komives (San Jose State) Bob Parker (Pittsburgh) Bob Parker (Pittsburgh)

4. FOSBE Conference Series FOSBE 2012 FOSBE 2012 October 21-25, 2012 October 21-25, 2012 Keio University campus, Tsuruoka, Japan Keio University campus, Tsuruoka, Japan Chair – Masura Tomita, Keio University Chair – Masura Tomita, Keio University Educational session organized Educational session organized CACHE has no direct financial commitment CACHE has no direct financial commitment FOSBE 2015 FOSBE 2015 Dates and location to be determined Dates and location to be determined Chair – Bob Parker, University of Pittsburgh Chair – Bob Parker, University of Pittsburgh CACHE financially responsible CACHE financially responsible FOSBE, the Future FOSBE, the Future Frank Doyle’s proposal for a partnership with IFAC Frank Doyle’s proposal for a partnership with IFAC

5. Future Plans: Teaching Modules Frank, Mike, Juergen and Wayne to flesh-out initial ideas for modules. Wayne: pharmacokinetic/pharmacodynamic models for subcutaneous delivery of insulin. Mike: steady-state and dynamic modeling of the glycolytic pathway Juergen: teaching modeling & numerical methods, systems biology

6. Future Plans: Teaching Modules Teaching modules for ChE core curriculum Teaching modules for ChE core curriculum Powerpoint lecture, simulation code, homework assignment Powerpoint lecture, simulation code, homework assignment Place on CACHE website under “Biosystems” Place on CACHE website under “Biosystems” Phase 1 Phase 1 5 modules to be developed by December 2013 5 modules to be developed by December 2013 Submit abstract to 2014 AIChE meeting Submit abstract to 2014 AIChE meeting Phase 2 Phase 2 5 more modules to be developed by other task force members by July 2014 5 more modules to be developed by other task force members by July 2014 Prepare submission for ChE Education by December 2014 Prepare submission for ChE Education by December 2014 Phase 3 - develop mechanism for submission of additional modules Phase 3 - develop mechanism for submission of additional modules