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Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies by Xiangguo Qiu, Jonathan Audet, Gary Wong, Stephane Pillet,

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Presentation on theme: "Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies by Xiangguo Qiu, Jonathan Audet, Gary Wong, Stephane Pillet,"— Presentation transcript:

1 Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies by Xiangguo Qiu, Jonathan Audet, Gary Wong, Stephane Pillet, Alexander Bello, Teresa Cabral, Jim E. Strong, Frank Plummer, Cindy R. Corbett, Judie B. Alimonti, and Gary P. Kobinger Sci Transl Med Volume 4(138):138ra81-138ra81 June 13, 2012 Published by AAAS

2 Fig. 1 ZMAb improves survival of EBOV-challenged NHPs. ( A ) Nine cynomolgus macaques were challenged with 1000 PFU of EBOV (red arrow). Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

3 Fig. 2 Clinical overview. Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

4 Fig. 3 EBOV-GP–specific antibody response. Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

5 Fig. 4 Cellular immune response in surviving animals 21 days after challenge. Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

6 Fig. 5 Identification of IL-2 and IFN-γ–producing cells upon in vitro stimulation by EBOV-GP peptide pools using flow cytometry. Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

7 Fig. 6 EBOV-GP sequences isolated from nonsurvivors. Xiangguo Qiu et al., Sci Transl Med 2012;4:138ra81 Published by AAAS

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