1. Cell Growth and Reproduction Chapter 9

2. Chapter Objective Describe the processes of cell growth and cell reproduction (SPI 3210.1.6.)

3. Section 9.1 The cell cycle multiplies cells

4. Section Objectives 1.Describe the structure and function of a chromosome. 2.Given a diagram or picture of a cell, identify whether the cell is in the interphase or mitotic phase of the cell cycle and explain what happens during each phase.

5. Key Terms chromatin chromosome sister chromatid centromere cell cycle interphase mitotic phase mitosis cytokinesis

6. Large Cells Can Have Problems!  As cells grow, their volume increases much more rapidly than their surface area!

7. Large cells may have difficulty supplying nutrients and expelling enough waste products. Why is size a problem?

8. Transport of Substances  Substances move by diffusion or by motor proteins.  Diffusion over large distances is slow and inefficient.  Small cells maintain more efficient transport systems.

9. Cellular Communications  The need for signaling proteins to move throughout the cell also limits cell size.  Cell size affects the ability of the cell to communicate instructions for cellular functions.

10. functionHow often a cell divides depends on the type of cell (its function). Eukaryotic cells that do divide undergo an orderly sequence of events known as the cell cycle. Cells Divide at Different Rates

11. The Cell Cycle  Cell division prevents the cell from becoming too large.  It also is the way the cell reproduces so that you grow and heal certain injuries.  Cells reproduce by a cycle of growing and dividing called the cell cycle.

12.  Interphase - the cell grows, carries out cellular functions, and replicates.  Mitosis - the cell’s nucleus and nuclear material divide.  Cytokinesis - a cell’s cytoplasm divides. The Cell Cycle

13. Phases of The Cell Cycle Interphase –G 1 (Gap 1 ) –S (DNA Synthesis) –G 2 (Gap 2 ) Mitotic (M) Phase Cytokinesis

14. The Cell Cycle

15. The Stages of Interphase  1 st stage - G 1  The cell is growing, carrying out normal cell functions, and preparing to replicate DNA.

16.  2 nd Stage – S  The cell copies its DNA in preparation for cell division. The Stages of Interphase

17. S phase Genetic material (chromosomes) duplicate)

18.  3 rd Stage - G 2  Cell prepares for division of nucleus (mitosis). The Stages of Interphase

19. Mitosis and Cytokinesis Concept 9.2 Cells divide during the mitotic phase

20. Section Objectives Given diagrams or pictures of cells in various stages of the mitotic phase of the cell cycle, identify and name the stages and explain what happens during each stage.

21. Key Terms prophaseprophase sister chromatidsister chromatid centromerecentromere spindle apparatusspindle apparatus metaphasemetaphase anaphaseanaphase telophasetelophase

22. Mitotic Phase Unique to eukaryotes Very accurate (error rate 1/100,000 cell divisions)

23. Centromere Chromosome duplication Sister chromatids Chromosome distribution to daughter cells Chromosome Prior to S phase Mitosis Duplicates the Nucleus (Chromosomes)

24. The Mitotic Phase

25. Stages of Mitosis Prison (Prophase) Men (Metaphase) Are (Anaphase) Thin (Telophase)

27. Prophase  The cell’s chromatin tightens.  Sister chromatids are attached at the centromere.  Spindle fibers form in the cytoplasm.

28.  The nuclear envelope seems to disappear.  Spindle fibers attach to the sister chromatids.

29. Metaphase  Sister chromatids line up in the middle of the cell.

30. Anaphase  Microtubules of the spindle apparatus begin to shorten.  Sister chromatids separate.  Chromosomes move toward the poles of the cell.

31. Telophase  The chromosomes arrive at the poles and begin to relax.  Two new nuclear membranes begin to form and the nucleoli reappear.  The spindle apparatus disassembles.

34. Process by which the cytoplasm of a cell is divided in two; usually follows mitosis and meiosis. Cytokinesis

35. Microfilaments constrict, or pinch, the cytoplasm to create a cleavage furrow Cytokinesis in Animal Cells

36. Cell wall too rigid for microfilaments to constrict cell. Cell plate created. Cytokinesis in Plant Cells

37. How Cytokinesis Differs in Plants

38. Section 9.3 Cell Cycle Regulation

39. Terms to know cyclincyclin cyclin-dependent kinasecyclin-dependent kinase cancercancer carcinogencarcinogen apoptosisapoptosis stem cellstem cell benign tumorbenign tumor malignant tumormalignant tumor metastasismetastasis

40. Normal Cell Cycle  Different cyclin/CDK combinations signal other activities, including DNA replication, protein synthesis, and nuclear division throughout the cell cycle.

41. Quality Control Checkpoints  Checkpoints in the cell cycle can stop the cycle if something goes wrong.

42. Apoptosis  Programmed cell death  Cells going through apoptosis actually shrink and shrivel in a controlled process.  Signals from the checkpoints can start apoptosis.

44. A disease caused by severe disruption of the mechanisms that normally control the cell cycle. Cancer

45. Abnormal Cell Cycle: Cancer  Cancer is the uncontrolled growth and division of cells.  Cancer cells can kill an organism by crowding out normal cells, resulting in the loss of tissue function.

46. Cancerous cells reproduce at an abnormally fast rate!

47. Benign: An abnormal mass of normal cells. Types of Tumors Malignant: A mass of abnormal cells resulting from uncontrolled cell division.

48. The spread of cancer cells beyond their original site Metastasis

49. Causes of cancer Genetic mutationsGenetic mutations FoodFood HormonesHormones RadiationRadiation TobaccoTobacco Weight & physical activityWeight & physical activity Workplace environmentWorkplace environment

50. Cancer Treatments SurgerySurgery Radiation therapyRadiation therapy ChemotherapyChemotherapy A mix of the threeA mix of the three

51. Stem Cells  Unspecialized cells that can develop into specialized cells when under the right conditions

52. Embryonic Stem Cells  After fertilization, the resulting mass of cells divides repeatedly until there are about 100–150 cells. These cells have not become specialized.

53. Adult Stem Cells  Found in various tissues in the body and might be used to maintain and repair the same kind of tissue  Less controversial because the adult stem cells can be obtained with the consent of their donor

54. chromatin: combination of DNA and protein molecules, in the form of long, thin fibers, making up the genetic material in the nucleus of a eukaryotic cell. chromosome: condensed threads of genetic material formed from chromatin as a cell prepares to divide. sister chromatid: one of a pair of identical chromosomes created during the S phase before a cell actually divides. Vocabulary Review

55. centromere: region where two sister chromatids are joined tightly together. Vocabulary Review (contd’) cell cycle: sequence of events from the production of a eukaryotic cell to the time the cell itself reproduces. interphase: stage of the cell cycle during which a cell carries out its metabolic processes and performs its functions in the body.

56. mitotic phase: stage of the cell cycle when a cell is actively dividing. mitosis: process by which the nucleus and duplicated chromosomes of a cell divide and are evenly distributed, forming two daughter nuclei. cytokinesis: process by which the cytoplasm of a cell is divided in two; usually follows mitosis and meiosis. Vocabulary Review (contd’)