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Supplementary table 1. Supplementary table 2 Supplementary table 3.

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Presentation on theme: "Supplementary table 1. Supplementary table 2 Supplementary table 3."— Presentation transcript:

1 Supplementary table 1

2 Supplementary table 2

3 Supplementary table 3

4 Supplementary table 4 A. B.

5 VALIDATED hsa-miR-155 TARGETS AGTR1 AICDA BCL2 CSF1R CTLA4 CUX1 ETS1 FGF7 IKBKE IL13RA1 INPP5D IRAK3 JARID2 MYD88 RIPK1 RNF123 SKI SLA SOCS1 SPI1 WEE1 Supplementary table 5

6 Supplementary table 6

7 Supplementary Fig. S1 A.B.C.

8 Flag-TRF1 actin MG132 siTRF1 -++ - control miR-155 1.002.551.132.05 2  g WB  -TRF1 MG132 siTRF1 -++ - control miR-155 Flag-TRF1 end. TRF1 actin 20  g WB  -TRF1 1.001.380.520.710.18end. TRF1/actin * B. C. A. TRF1 mRNA levels normalized to actin (con.miRNA set “1”) n=3 p=0.3 p=0.2 p=0.012 Supplementary Fig. S2 Flag-TRF1/actin

9 Supplementary Fig. S3 miR-155 signature low: n=593 miR-155 signature high: n=606 ER positive tumors

10 Supplementary Fig. S4 B.A. miR-155 a-miR-155 control 6000 5000 4000 3000 2000 1000 0 7000 8000 TRF1 fluorescence intensity (a.f.u) 1312 ±30.52 n=602 N=41 1051 ±31.08 n=512 N= 40 1464 ±37.79 n=508 N= 31 p<0.0001 control miR-155 antago- miR-155 TRF1TRF1/DAPI antago- miR-155 MBA-MD-468 U 2-OS D. C. miR-155 a-miR-155 control 2000 4000 6000 8000 10000 12000 14000 16000 18000 20000 POT1 fluorescence intensity (a.f.u) 1199 ±101.7 n=1199 N=35 p=0.119 p=0.071 1552 ±86.24 n=1552 N= 37 985 ±101.4 n=985 N= 30 control miR-155 antago- miR-155 POT1POT1/DAPI 5000 1000 10000 miR-155 a-miR-155 control TRF2 fluorescence intensity (a.f.u) 15000 1619 ±54.45 n=1173 N=48 p=0.4 p=0.065 1584 ±41.40 n=1267 N= 48 1694 ±51.07 n=1050 N= 48 control miR-155 antago- miR-155 TRF2TRF2/DAPI

11 TRF2 mRNA levels normalized versus actin n=3 p=0.2 TRF1 mRNA levels normalized versus actin n=3 p=0.2 miR-155 levels normalized versus RNU46 n=3 p<0.0001 control miR-155 TRF1 protein levels normalized versus actin n=3 p=0.01 A.B. D. C. E. TRF1 actin Supplementary Fig. S5 telomere length (a.f.u.) A B C 1591 ± 30.72 N=42 n=3823 1916 ± 37.47 N=39 n=3521 p<0,0001 2000 10000 12000 14000 16000 4000 6000 8000 0 control miR-155 telomere a.f.u intesisty categories (%)

12 p=0.035 N=3 n=50 N=3 n=50 TIF frequency (2< TIFs; %) miR-155 levels, normlized to RNU46 (con set “1”) control miR-155 control miR-155 TRF1 actin TIF frequency 3< TIFs; %) p=0.05 N=3 n=81 N=3 n=93 Supplementary Fig. S6 A. B.C.D.

13 n=1370 n=1533 N=17 N=20 p= 0,03 fragile telomeres (%) Supplementary Fig. S7 A. N=40 n=3084 N=40 n=3098 p=0,003 fragile telomeres (%) B. C.D. N=25 n=1974 N=25 n=1906 p= 0,04 fragile telomeres (%) - + - - + + Aphidicolin con.miRNA antago-miR-155 - + - - + + Aphidicolin con.miRNA p=0.05 N=26 n=2134 N=21 N=1542 telomeric sister chromatid fusions (%)

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