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Online – animated web site http://www.sciencegeek.net/Biology/review/U 5Storyboard.htm
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Name Date Period Take notes here Summary – one summary at the end Questions “Cornell Style” Chapter 12 DNA
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Function of DNA: §Stores genetic information. §Tells a cell what to do. “instructions”, “directions”, “recipe” Structure: Double helix made of nucleotides Nucleotide made of 3 parts. 1. 5-carbon sugar (Deoxyribose) 2. Phosphate group 3. Base
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Bases: PurinesPyrimidines AdenineThymine GuanineCytosine hydrogen bonds “GCAT”
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1. DNA unzips 2. Base pairs attach 3. 1 / 2 old & 1 / 2 new “to copy”
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DNA replication CATG C CAAGG GGACTTTC
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CATGCAAGG CGGACTTTC one strand acts as template for a new one
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one C G A T DNA nucleotides
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one G C
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GG CC covalent bond formed catalyzed by DNA polymerase
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GAG CTC
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GAGC CTCG
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GATGC CTACG
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GATGCT CTACGA
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GATGCTC CTACGAG
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GATGCTTC CTACGAAG
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DNA replication CATGCAAGG CGGACTTTC one strand acts as template for a new one GATGCTTCC CTACGAAGG
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DNA replication CATGCAAGG CGGACTTTC “semiconservative” replication GATGCTTCC C TACGAAGG old strand new strand
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RNA Function: To move genetic information from the nucleus to the cytoplasm. Structure: Made of nucleotides (sugar, phosphate, base) 3 Types of RNA 1. “messenger” mRNA – transcribes DNA’s message 2. “ribosomal” rRNA – translates the mRNA 3. “transfer” tRNA – carries amino acids
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Difference between RNA & DNA 1. The sugar is Ribose in RNA 2. RNA is single stranded 3. RNA uses Uracil instead of Thymine
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DNA G C T A RNA C G A U
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(Protein Synthesis) 1.mRNA is transcribed from DNA 2.mRNA leaves nucleus 3.mRNA travels to a ribosome 4.the ribosome (rRNA) translates the mRNA 5.tRNA brings the correct amino acid 6.the amino acids link together to form a protein “To Make”
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Nuclear membrane tRNA Amino acid Protein Cell membrane Ribosome 1 2 3 4 5 6
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CATG C CAAGG GGACTTTC info.DNA strand
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CATG C CAAGG GGACTTTC info.DNA strand code for an amino acid
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CATG C CAAGG GGACTTTC info.DNA strand code for another amino acid
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transcription CGGACTTTC CUAG info.DNA strand RNA nucleotides
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transcription CGGACTTTC C info.DNA strand
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transcription CGGACTTTC C info.DNA strand C covalent bond formed catalyzed by RNA polymerase
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transcription CGGACTTTC CU info.DNA strand C
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transcription CGGACTTTC CUG info.DNA strand C
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transcription CGGACTTTC CUG info.DNA strand CA
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transcription CGGACTTTC CUG info.DNA strand CAA
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transcription CGGACTTTC CUG info.DNA strand CGAA
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transcription CGGACTTTC CUAG info.DNA strand CGAA
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transcription CGGACTTTC info.DNA strand CUAGCGGAA
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transcription CGGACTTTC CUAG info.DNA strand C G GAA part of messenger RNA
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mRNA CUAGCGGAA Every 3 bases is a code “CODON” for an amino acid. Codon
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How does the tRNA know what amino acid to bring? §It uses the genetic code table.
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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CUAGCGGAA site on ribosome codon mRNA
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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CUAGCGGAA AGG proline mRNA tRNA amino acid codon anticodon
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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CUAGCGGAA AGG proline UUC glutamate mRNA
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CUAGCGGAA AGG proline UUC glutamate peptide bond forms mRNA
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CUAGCGGAA AGG proline UUC glutamate tRNA released mRNA
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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CUAGCGGAA proline UUC glutamate CUC
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CUAGCGGAA proline UUC glutamate CUC Protein
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Termination of protein synthesis §3 STOP codons §protein released
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1st Base the genetic code 2nd Base 3rd Base U C A G phenylalanine leucine isoleucine methionine valine serine proline threonine alanine tyrosine STOP histidine glutamine asparagine lysine aspartate glutamate cysteine STOP tryptophan U C A G arginine serine glycine U C A G U C A G U C A G U C A G
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