1. Pain Day – The Basics of Pain
Randall Reed PhD
Director Center for Sensory Biology
Professor
Department of Molecular Biology and Genetics
Department of Neuroscience
Department of Otolaryngology – HNS

2. Our Senses Share Many Common Properties
The IBBS Center for Sensory Biology
Randall Reed - olfaction
Paul Fuchs - hearing
Michael Caterina - Pain/touch
Xinzhong Dong - Pain/touch
Craig Montell - vision/taste
Elisabeth Glowatzki - hearing
Jeremy Nathans - vision
King-Wai Yau - vision/olfaction
Angelika Doetzlhofer – hearing
Michael Deans - hearing

3. Classic View of the Senses
The Five Senses - Provide Information
Vision
Smell
Taste
Hearing
Touch
Also Provide Protection

4. The Spectrum of Sensations
Pain from a Broad Perspective:
Touch
Itch
Pain

5. TRP Channels: Molecular Gatekeepers for the Senses
TRP Channels Mediate:
Thermal Sensation / Pain
Taste
Some aspects of:
Vision
Olfaction
Hearing

6. The Senses: Targets of Environmental Assault
Sensory Systems lie at interface between our inner and outer world – Subject to Damage
Hearing Loss
Burn/Itch
Olfactory Loss
Light Induced Damage

7. Key Opportunities/Practical Implications of Advances in Sensory Biology
Strategies to modulate (up or down) sensory perception (Pain/Auditory/Chemosensory)
Organization/Interaction of cells in tissues
Molecular and cellular genesis of specialized organelles
Understand processes of neuronal damage, repair and regeneration