1. Skin and Soft Tissue Infections

2. Vesicles Clinical SyndromeInfectious Agent SmallpoxVariola Virus ChickenpoxVaricella-zoster virus Shingles (herpes zoster)Varicella-zoster virus Cold sores, herpetic whitlow, herpes gladiatorum Herpes simplex virus Hand-foot-and-mouth disease Coxsackie virus OrfParapoxvirus Molluscum ContagiosumPox-like virus RickettsialpoxRickettsia akari Blistering distal dactylitisStaphylococcus aureus or Streptococcus pyogenes

3. Bullae Clinical SyndromeInfectious Agent Staphylococcal scalded-skin syndrome S. aureus Necrotizing fasciitis S. pyogenes, Clostridium spp., mixed aerobes and anaerobes Gas gangreneClostridium spp. Halophilic vibrioVibrio vulnificus

4. Crusted lesions Clinical SyndromeInfectious Agent Bullous impetigo/ecthyma S. aureus Impetigo contagiosaS. pyogenes RingwormSuperficial dermatophyte fungi SporotrichosisSporothrix schenckii HistoplasmosisHistoplasma capsulatum CoccidioidomycosisCoccidioides immitis BlastomycosisBlastomyces dermatitidis Cutaneous leishmaniasis Leishmania spp. Cutaneous tuberculosis Mycobacterium tuberculosis NocardiosisNocardia asteroides

5. Folliculitis Clinical Syndrome Infectious Agent FurunculosisS. aureus Hot-tub folliculitis Pseudomonas aeruginosa Swimmer's itchSchistosoma spp. Acne vulgarisPropionibacterium acnes

6. Papular and Nodular lesions Clinical SyndromeInfectious Agent Fish-tank or swimming-pool granuloma Mycobacterium marinum Creeping eruption (cutaneous larva migrans) Ancylostoma braziliense DracunculiasisDracunculus medinensis Cercarial dermatitisSchistosoma mansoni Verruca vulgarisHuman papillomaviruses 1, 2, 4 Condylomata acuminata (anogenital warts) Human papillomaviruses 6, 11, 16, 18 Onchocerciasis noduleOnchocerca volvulus Cutaneous myiasisDermatobia hominis Verruca peruanaBartonella bacilliformis Cat-scratch diseaseBartonella henselae Lepromatous leprosyMycobacterium leprae Secondary syphilis (papulosquamous, nodular, and condylomata lata lesions) Treponema pallidum Tertiary syphilis (nodular gummatous lesions) T. pallidum

7. Ulcer with or without eschars Clinical Syndrome Infectious Agent AnthraxBacillus anthracis Ulceroglandular tularemia Francisella tularensis Bubonic plagueYersinia pestis Buruli ulcerMycobacterium ulcerans LeprosyM. leprae Cutaneous tuberculosis M. tuberculosis ChancroidHaemophilus ducreyi Primary syphilisT. pallidum

8. Erysipelas Infectious Agent: S. Pyogenes

9. Cellulitis Infectious Agent: Staphylococcus spp., Streptococcus spp., various other bacteria

10. Necrotizing fascitiis Clinical SyndromeInfectious Agent Streptococcal gangreneS. pyogenes Fournier's gangreneMixed aerobic and anaerobic bacteria Staphylococcal necrotizing fasciitis Methicillin-resistant S. aureus

11. Myositis and Myonecrosis Clinical SyndromeInfectious Agent PyomyositisS. aureus Streptococcal necrotizing myositisS. pyogenes Gas gangreneClostridium spp. Nonclostridial (crepitant) myositisMixed aerobic and anaerobic bacteria Synergistic nonclostridial anaerobic myonecrosisMixed aerobic and anaerobic bacteria