1. 2015.05.27 Grounding the Human Body Improves Facial Blood Flow Regulation Chevalier, G. (2014). Grounding the Human Body Improves Facial Blood Flow Regulation: Results of a Randomized, Placebo Controlled Pilot Study. Journal of Cosmetics, Dermatological Sciences and Applications, 4(05), 293. Presenter ： Wei-Siang Ciou Adviser ： Dr.Yi-Chun Du 1

2. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Introduction  Materials and methods  Results  Conclusion 2 Outline

3. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 3 Introduction

4. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Improved sleep  Decreased pain  A normalizing effect on cortisol  Reduction of stress 4 Earthing can be beneficial

5. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Diminished damage to muscles  Muscle soreness  Immune response  Blood fluidity 5 Earthing can be beneficial

6. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 6 Easily into one’s daily life https://www.earthing.com/

7. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 7 Materials and methods

8. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 8 GroundedControls FemaleMaleFemaleMale No. of Subjects 20794 Average Age 54.255.658.747.8 Age SD 10.212.16.488.73 Subjects

9. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Pregnancy  Below the age of 18 or above 70  Taking pain, anti-inflammatory medication, sedatives or prescription sleeping medication  Taking psychotropic drugs or diagnosed with mental disorder 9 Exclusion criteria

10. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Recent surgery (less than 3 months)  Documented life threatening disease (such as cancer and AIDS)  Consumption of alcohol within 48 hours of participation 10 Exclusion criteria

11. 生醫系統整合實驗室 Integrated Biomedical System Laboratory  Smoking  Use of recreational drugs  Previous utilization of Earthing products or similar grounding products  Going barefoot outside more than once a week and for more than half hour 11 Exclusion criteria

12. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 12 Speckle image of quiescent objects Speckle images of moving objects Laser Speckle Contrast Imaging (LSCI)

13. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 13 CCD Camera

14. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 14  Capability of recording up to 25 images per second  In the present study, an intermediate frame rate of 10 FPS was used. CCD Camera

15. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 15 Procedure Grounded TENS patches Conductive mats Lasted approximately one hour

16. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 16 Double-blind Grounded Sham-Grounded

17. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 17 Results of Grounded Subjects

18. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 18 Female, Caucasian, 33 Flux at 11 minutes 50 secondsFlux at 45 minutes 10 seconds

19. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 19 Results Same graph of mean FBF over time corrected for movement artifacts and smoothed.

20. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 20 Female, Caucasian, 55 Flux at 28 minutes and 40 seconds Flux at 56 minutes and 40 seconds

21. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 21 Results Same graph of mean FBF over time corrected for movement artifacts and smoothed.

22. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 22 Results-Sham Grounded Subjects

23. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 23 Female, Caucasian, 55 Flux at 20 minutesFlux at 79 minutes

24. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 24 Results Same graph of mean FBF over time corrected for movement artifacts and smoothed.

25. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 25 Female, African-American, 68 Flux at 20 minutesFlux at 43 minutes

26. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 26 Results Same graph of mean FBF over time corrected for movement artifacts and smoothed.

27. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 1.The Earth we live on possesses a form of easily accessible and beneficial natural electric energy 2.Positively influence human physiology in various ways 3.A clear improvement of facial blood flow in grounded subjects but not in sham-grounded subjects 27 Conclusion

28. 生醫系統整合實驗室 Integrated Biomedical System Laboratory 4.Restores blood flow regulation to the face that may enhance skin tissue repair, health and vitality, and optimize facial appearance 5.May also have broad implications for overall cardiovascular function and health 28 Conclusion

29. 生醫系統整合實驗室 Integrated Biomedical System Laboratory Thank you for your attention! 29 http://faculty.stust.edu.tw/~terrydu/