1. Wild Type Drosophila

2. Ommatidium 8 Photoreceptor cells (R1-R8) 4 Cone cells (secrete lens) 8 Pigment cells

3. Wild Type Eye Phenotype

4. Eyeless Mutant Phenotype (hypomorphic allele)

5. DNA Paired Domain Protein

6. Figure 1A LacZ No Transcription of LacZ Gal4 Enhancer-Trap Method

7. Figure 1A LacZ Enhancer that controls expression in specific tissues Gal4 Enhancer-Trap Method

8. Figure 1A LacZ Tissue-specific Expression of Gal4 Gal4 Enhancer-Trap Method Tissue-specific Expression of LacZ

9. Figure 1 Eye-Antennal disc wing disc leg disc

11. Figure 1A LacZ Gal4 Enhancer-Trap Method Enhancer that controls expression in imaginal disc cells Transcription of LacZ in imginal disc cells

12. Figure 1A Enhancer that controls expression in imaginal disc cells Transcription of eyeless in imginal disc cells

13. Figure 2

14. Figure 3

15. DNA Paired Domain Protein Drosophila ey, mouse Pax-6 (sey) and Human Pax-6 (Aniridia) genes are ~ 94% similar in Paired domain

16. Enhancer that controls expression in imaginal disc cells Transcription of Pax-6 in imginal disc cells Pax-6 Ectopic Expression of Mouse Pax-6 Gene

17. Figure 5 Ectopic Expression of Mouse Pax-6 Gene

18. Aniridia -- Human Pax-6 Mutation Absence of the iris

23. Xenopus Oocyte Animal Pole Vegetal Pole

24. Xwnt-11 mRNA Localization Xwnt-11 is Drosophila wingless homogue

25. Normal Ventralized

26. Embryo Grafting Experiment

28. Goosecoid Protein Expression

29. Embryo Grafting Experiment Inject mRNAs For Chordin etc.

31. Formation of ventral structures

33. Normal Dorsalized