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Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction by Tashera E. Perry, Minjung Song, Daryl J.

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Presentation on theme: "Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction by Tashera E. Perry, Minjung Song, Daryl J."— Presentation transcript:

1 Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction by Tashera E. Perry, Minjung Song, Daryl J. Despres, Soo Mi Kim, Hong San, Zu-Xi Yu, Nalini Raghavachari, Jurgen Schnermann, Richard O. Cannon, and Donald Orlic Cardiovasc Res Volume ():cvp215 July 21, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

2 (A) Circulating white blood cells were analysed by flow cytometry to determine the percent chimerism. Tashera E. Perry et al. Cardiovasc Res 2009;cvr.cvp215 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

3 (A) EGFP expression was detected by western blot analysis in heart, kidney, and spleen of EGFP+ controls and BM-transplanted eNOS−/− mice but not in eNOS−/− control mice. Tashera E. Perry et al. Cardiovasc Res 2009;cvr.cvp215 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

4 Confocal microscopy of conducting arteries in heart, kidney, liver, and spleen in EGFP+ control mice are seen in (A–D). Tashera E. Perry et al. Cardiovasc Res 2009;cvr.cvp215 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

5 Confocal microscopy of conducting arteries in heart, kidney, liver, and spleen in EGFP+ control mice are seen (A–D). Tashera E. Perry et al. Cardiovasc Res 2009;cvr.cvp215 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

6 Confocal microscopic images of several aortas are seen in (A–E). Tashera E. Perry et al. Cardiovasc Res 2009;cvr.cvp215 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

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