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LYSOSOMES By: Carmelitta Oakley
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Lysosomes Characteristics: Acidic interior Contains hydrolytic enzymes
Surrounded by a membrane Lysosomes are analogous to the human stomach; the pH within a lysosome is very acidic & the enzymes within work most effectively in this environment.
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Functions: Carrying out digestion recycling of cellular organelles
the breakdown of viruses and other cellular invaders Single-celled organisms, such as amoebas, use lysosomes to digest their food since they have no process for extracellular digestion.
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Lysosomal storage diseases
Undegraded material accumulates within the lysosomes of affected individuals Most of these diseases result from deficiencies in single lysosomal enzymes. Example: Gaucher’s disease
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Gaucher disease Most common of lysosomal storage diseases
Genetic disorder where there’s accumulation of lipids in cells and organs results from a mutation in the gene that encodes a lysosomal enzyme required for the breakdown of glycolipids.
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Some Signs & Symptoms: Enlarged liver and spleen
Low number of red blood cells (anemia) easy bruising caused by a decrease in blood platelets lung disease bone abnormalities such as bone pain, fractures, and arthritis. Problems with central nervous system
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