1. the Future is here & now

3. The Therapeutic development has two hearts and one soul

4. for critical care staff The simplicity of using one single system for the widest variety of treatments The serenity of automated and simple management of complex treatments 24h/24h. The reduction and optimization of the number and time of the operation

5. for Clinicians A big and important therapeutic choice An advanced and targeted personalization capability Complete control of the therapeutic process

6. Critical Care Strategy SEPSIS MOF Multi-organ failure ALI SIRS Liver Failure AKI HYPERCHOLESTEROLEMIA DEGENERATIVE MACULOPATHIES DIABETIC FOOT RHEUMATOID ARTHRITIS MYASTHENIA GRAVIS GUILLAIN-BARRÈ SYNDROME GLOMERULONEPHRITIS ARDS many diseases in ONE equipment RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD Specific and effective therapies

7. RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies Specific Sorbents COMPLETENESS

8. Hemofilter Plasmafilter Citrate CaCl 10% Post dilution Uf Mediasorb CPFA with Citrate COMPLETENESS

9. COMPACT study results In-hospital Intensive Care Mortality controls Tertiles CPFA dose (L/Kg) Mortality rate in-hospital and in Intensive Care units for CPFA dose in 3 days of treatment The study explain that if we perform the CPFA with right dose of plasma, the mortality change from. 55,2% Vs 25,8% Relative Risk= 46% Personalized CPFA management with controlled servo-assisted flow AUTOMATION

10. RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies COMPLETENESS

11. CASCADE FILTRATION PLASMAFILTRO PLASMA For the removal of : CIC (Circulating Immune Complexes) IgM IgG Triglycerides Lipoproteins In case of: Hypercholesterolemia Degenerative maculopathies Diabetic foot Rheumatoid arthritis Myasthenia Gravis Guillain-Barrè Syndrome.

12. CASCADE Rinsing LIQUIDO DI LAVAGGIO PLASMAFILTRO

13. RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies COMPLETENESS

14. Uf O2 CO2 HD Dialysate flow

16. Multiorgan Dysfunction: many medical devices?