1. Munich, Germany 17-21 June 2007ECBO 2007 Static depth dependent dispersion compensation in a real-time static delay line grating-based correlation OCT system L. Froehly, P. Sandoz, L. Furfaro, M.Ouadour Institut FEMTO-ST; Département d’Optique P.M. Duffieux Besançon, France

2. Munich, Germany 17-21 June 2007ECBO 2007 Dispersion problem in OCT 100  m Dispersion limits axial resolution Dispersion depends on the material thickness Dispersion decreases the Signal to Noise ratio

3. Munich, Germany 17-21 June 2007ECBO 2007 Hardware correction S.L.S. M1M1 S1S1 O1O1 O2O2

4. Munich, Germany 17-21 June 2007ECBO 2007 Hardware correction (rapid scanning delay line) K. F. Kwong, D. Yankelevich, K. C. Chu, J. P. Heritage, and A. Dienes, Opt. Lett. 18, 558- (1993) ->first demonstration for pulse measurements Rollins, S. Yazdanfar, M. Kulkarni, R. Ung-Arunyawee, and J. Izatt, Opt. Express 3, 219-229 (1998) G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, Opt. Lett. 22, 1811-1813 (1997) ->Application of the system to TD-OCT system

5. Munich, Germany 17-21 June 2007ECBO 2007 Numerical correction Phase correction in Fourier space Influence of the phase correction on the image contrast Quite time consuming

6. Munich, Germany 17-21 June 2007ECBO 2007 Grating-based Tomographic system y z S.L.S. S1S1 M..: Mirror S: Polarizing beam splitter L 1 : Spherical lens S.L.S. : White light laser source C.B. : Polarizing beam splitter D : CCD R : Diffraction grating 530 gr/mm P : prism O… : Miroscope objectives E : Sample I (z) ztzt L1L1 M2M2 M3M3 C.B. D P O1O1 O2O2 R

7. Munich, Germany 17-21 June 2007ECBO 2007 M3M3 M2M2 R Principle I x↔z

8. Munich, Germany 17-21 June 2007ECBO 2007 y z S.L.S. S1S1 I (z) ztzt L1L1 M2M2 M3M3 C.B. D P O1O1 O2O2 R Absorption L. Froehly, M. Ouadour, L. Furfaro, P. Sandoz, T. Gharbi et al, Real-time optical coherence spectrotomography : proof of principle volume 6191 of Biophotonics and New Therapy Frontiers. SPIE, Apr. 2006.

9. Munich, Germany 17-21 June 2007ECBO 2007 z z Optical Depth dependant dispersion compensation z

10. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : principle

11. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : principle

12. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : principle

13. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : validation

14. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : validation

15. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : validation

16. Munich, Germany 17-21 June 2007ECBO 2007 Optical Depth dependant dispersion compensation : validation

17. Munich, Germany 17-21 June 2007ECBO 2007 Future directions: lens effect on dispersion

18. Munich, Germany 17-21 June 2007ECBO 2007 Future directions : lens effect on dispersion

19. Munich, Germany 17-21 June 2007ECBO 2007 Future directions : catadioptrics systems y z S.L.S. S1S1 M2M2 M3M3 C.B. P O1O1 O2O2 R D

20. Munich, Germany 17-21 June 2007ECBO 2007 Aknowldegments French ANR who finances this project Leukos innovative systems who provide us with microchip-based supercontinuums