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TPS & Simulations within PARTNER D. Bertrand, D. Prieels Valencia, SPAIN 19 JUNE 2009
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© 2006 2 TPS & simulations within PARTNER CERN CNAO GSI HIT Karolinska Surrey TERA IBA Siemens MedAustron IFIC ETOILE PARTNER = Clinical studies, Epidemiology, Radiobiology, TPS, Simulations, Image guided particle therapy, PET In-situ monitoring, Gantry design, new accelerator design. ESR : 6/20 = 30% activity ER: 1/5 = 20% activity
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© 2006 3 Detailed TPS scope (P4) Research will focus on external ion beam therapy techniques and on adaptive treatments based on combined modalities: Appropriate model of particle beam spots (spatial distribution, dose deposition) Study the requirements on the mathematical structure of models Optimization of algorithms for model evaluations Introduction of biological models for photon radiation into treatment planning Treatment plan optimization based on biological modelling Dose assessment with a special attention to the heterogeneities Biology-based segmentation within the structures (hypoxic regions, dose-volume limits based on LET differences) Robustness against volume changes Treatment strategies based on outcome analysis: assessment of tumor control and normal tissues toxicity Multidimensional dosimetric verification including portal dosimetry Planning for novel treatment delivery modalities Analytical or hybrid approaches Comparative assessment of different Monte-Carlo approaches (Geant4, FLUKA, SHIELD-HIT)
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© 2006 4 Detailed Simulation scope (P5) Research will focus on facilitating the use of GEANT and FLUKA for medical therapy applications: Collect of available information on the simulation of different ion species used in particle therapy Simulation, for these different ion species, the relevant physical processes (such as neutron production and capture, break-ups and generation of secondaries,…) Development of a basic data generation tool Understanding of the interactions of ion beams with materials of the human body Generation of reference codes for clinical use Benchmarking of treatment planning algorithms by comparison of output plans to MC models Use of simulation data for optimising or confirming the choices of ion species Transfer of available Monte Carlo simulation tools for industrial applications (for treatment planning or beamline design)
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© 2006 5 TPS - ESR / ER individual projects WP 10 – Clinical effects of hadron therapy (Surrey) Multiscale In-silico models describing the clinical effects of hadron beams Acquisition of simulation input parameters through single ion irradiation experiments
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© 2006 6 TPS - ESR / ER individual projects WP 11 – TPS robustness against volume deformations (MedAustron, IBA) CT data acquisitions reflecting inter- and intra- fractional changes Computation of fractionated plans, image deformation and registration Assessment of treatment strategies in the presence of inter- and intra-fractional deformations
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© 2006 7 TPS - ESR / ER individual projects WP12 – Geant4/GATE Monte Carlo platform (IBA, Etoile) Elaboration of a detailed MC model for proton and carbon ion therapy Assessment of beam physical characteristic and therapeutic quality Computation of relevant parameters for radiobiological modelling Assessment of TPS output
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© 2006 8 TPS - ESR / ER individual projects WP13 – Treatment plan with combined modalities (MedAustron, Etoile) Assessment of tumor changes that might require combined treatments Definition of relevant combined strategies (photons + protons, photons + carbons) Calculation of separate plans and reconstruction of the overall plan
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© 2006 9 Simus - ESR / ER individual projects WP14 – Comprehensive reference MC codes for hadron therapy (CERN) Comparison of existing MC codes (G4, FLUKA, Shield-HIT) for their simulation of biomedical effects Simulate the key physical processes undergone by clinical ion species Generate basic input data for TPS benchmarking
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© 2006 10 Simus - ESR / ER individual projects WP15 – FLUKA customisation for plan verifications (HIT) Customisation of FLUKA in the HIT research planning platform Computation of dose depositions and comparison with treatment plan data Experimental validation with homogeneous and heterogeneous phantoms Integration of MC-based verification of treatment plans in an efficient clinical workflow
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© 2006 11 Simus - ESR / ER individual projects WP16 – FLUKA & Geant4 simulations at Siemens Healthcare PT (Siemens) Setup a simulation environment for carbon ions & protons Develop, test and document the interface between treatment planning and the simulation environment Determine the characteristic numbers for the comparison between TPS and simulation platform
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© 2006 12 What comes out of these research topics? Research on key TPS aspects (physical processes, biological effetcs, optimisation) => Training of high-quality TPS experts Clear overlap between multiple projects, even if clear independant objectives for all of them Already some connexion between researchers; more should be developed => Creation of a real collaborative framework through PARTNER
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© 2006 13 Thank you!
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