1. Day DateReadingTopic T 9/3 pp.216-231 (Ch. 6) C. elegans, model systems, and molecular genetics Watch three Audio/Video handouts: 1A), 1B), and 1C Th9/5Ch. 1An introduction to developmental biology T9/10 QUIZ 1 (covers A/V Handouts 1A, 1B, and 1C) More introduction Watch two Audio/Video handouts: Review of transcription regulation, Parts 1 and 2 Th9/12Ch. 3Vertebrate life cycles T9/17 QUIZ 2(covers A/V Handouts 2A and 2B) Vertebrate axes and germ layers Th9/19 CH. 4Vertebrate axial patterning T9/24More vertebrate body plan Th9/26Ch. 5Early patterning of vertebrate nervous systems T10/1exam date changed Th10/3 Ch. 2Molecular development of Drosophila T10/8EXAM 1Chapters 1, 3, 4, and pp216-231 Lectures and Handouts Th10/10Ch. 7Plant development On Thursday, 10/10, please bring a copy of the primary research article you have selected (or more than one if you haven’t decided) plus your notes on the article.

2. Chapters 3 and 4 cover early patterning of all vertebrates

3. Fig. 3.17

4. Xenopus laevis

5. Fig. 3.4

8. Fig. 3.28

10. Fig. 3.29

11. Fig. 3.30

12. Fig. 3.44

16. Fig. 3.55

17. Ch. 4 Summary

18. Fig. 3.48

23. morphogens neurons neural tube

25. For EXAM #2

26. Box 4A wild-type fruit fly antennapedia mutant

27. The Hox gene family are examples of homeotic genes. Homeotic genes are genes that when mutant cause a change in the spatial position of structures (change in address). Box 4A wild-type fruit fly antennapedia mutant

28. The Hox gene family are examples of homeotic genes. Homeotic genes are genes that when mutant cause a change in the spatial position of structures (change in address). Box 4A

29. The Hox gene family are examples of homeotic genes. The Hox gene products give the positional address along the Anterior-Posterior (A/P) axis in all animals. Box 4A

30. The Hox gene family are examples of homeotic genes. The Hox genes encode a family of paralogous proteins that are sequence-specific DNA-binding transcription factors.

31. The Hox gene family are examples of homeotic genes. The Hox proteins bind to response elements in the promoter DNA of target genes. The DNA-binding domain of the protein is called the homeodomain:

32. The Hox gene family are examples of homeotic genes. Hox proteins work in a combinatorial manner to determine A/P axis address. Fig. 4.9

33. Figs. 4.27, 4.28

34. Fig. 5.3

35. Fig. 5.18

36. Fig. 5.20

37. Fig. 5.29

38. %ig. 5.31