1. Pathway: a collection of genes, proteins, and /or small molecules that modulate a cellular process or disease state Growing demand in biological sciences to perform “pathway analysis” on omic data sets Common Goals: build pathway maps obtain insight not provided by specific gene/protein/metabolite- level analyses drug development: targeting pathways may improve cancer therapy (since cancer cells can acquire resistance to targeting single nodes) PATHWAY ANALYSIS FROM RECENT WEBINAR – DR. PHIL LORENZI EXPLORING AUTOPHAGY IN CANCER WITH PATHWAY STUDIO

2. Which genes and proteins modulate the autophagy pathway? Which genes represent candidate targets for cancer therapy? KEY QUESTIONS

3. INTEGRATED ANALYSIS OF SI RNA + PATHWAY DATA

4. NAVIGATING AN OCEAN OF DATA… More breadth: At least 2X more journal titles have been analyzed for PS More coverage: At least 3-4X more journal articles have been analyzed for PS More depth: At least 6x more full-text articles have been mined for relationship data Fast updates: PS updates content weekly. IMPROVING R&D EFFICIENCY Apply knowledgebase content, powerful algorithms, flexibility, ease of use and best-of- class visualization to transform experimental data into actionable findings. PATHWAY STUDIO

5. MAKE CONNECTIONS Knowledgebase of >3.3 million molecular facts Inference algorithms to make new findings Direct access to >15 million sentences of evidence REVEAL BIOLOGY DRIVE NOVEL INSIGHTS Interactive tools to create de novo molecular models Library of >800 pathways for inspection and analytics Best of class graphics for data mining and to publish Connecting individual research findings from the knowledgebase to gain fresh understanding, and to obtain novel insights. Apply knowledgebase content, powerful algorithms, and best-of-class visualization to transform experimental data into actionable findings. Apply your proprietary information and leverage reference pathways to produce models which explain and communicate complex biology.

7. Whether your research is focused on discovering new drug targets or biomarkers, repurposing existing drugs, or doing basic biological research, Elsevier’s Pathway Studio can help you analyze your experimental data to answer questions like: Which proteins are highly regulated in my disease of interest? What other functionally-related molecules might be associated with my candidate biomarker? Which proteins should I use for binding studies for this drug candidate? PATHWAY STUDIO

8. WHAT IS MEDICINAL CHEMISTRY? Disease

9. … BUT IT'S NOT THAT SIMPLE, MEDICINAL CHEMISTS FOR INSTANCE NEED TO COLLECT, ORGANIZE AND COMPARE INFORMATION FROM DIFFERENT SOURCES… THIS IS TIME CONSUMING AND ERROR PRONE ? ? ? ?

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