1. CORRELATION BETWEEN IMAGISTIC AND PATHOLOGIC FINDNGS IN CEREBRAL MENINGIOMA
First author: Laura Maria Frîncu Coordinator: Prof. Dr. Mircea Buruian
Second author: Dr. Mihaela A. Dobra
Adelina Mãcesanu
Marisiensis 2015

2. meningioma symptomatic/asymptomatic
is a tumor that arises from the meninges
the most common intracranial primary neoplasm in adults (13-25%)
meningioma
higher incidence among women as compared to men (2:1)
symptomatic/asymptomatic
mean age ranges between years old

3. Elizabeth Taylor Academy– award winning actor, star of numerous movies
Michelle Stafford  
Actress on the soap opera “ The young and the restless”
Sheryl Crow Singer, diagnosed with meningioma in 2012

4. Nowadays
Harvey Cushing
1922
Felix Plater

6. IMAGING FEATURES and the PATHOLOGICAL GRADE
Aim:
correlations between specific preoperative
IMAGING FEATURES and the
PATHOLOGICAL GRADE
in patients with meningiomas

7. retrospective study
289 patients
MATERIAL AND METHODS

8. histopathological examination
WHO
classification
surgical treatment
CT and MRI scans
All data were analyzed with Microsoft Excel, SPSS, GraphPad- Chi-squared test

9. % 7.6% SPSS 15,3 men 82% 2% atypical transitional 24-83 80.9% edema
11.4%
SPSS
80.9%
meningioma
ANALASTIC
edema
atypical
EXCEL
15,3
women
7.6%
82%
transitional

10. Gender distribution

11. Age distribution

12. World Health Organization (WHO) Meningioma Classifications
WHO Grade I —  Benign
WHO Grade II —  Atypical
WHO Grade III —  Malignant
Meningothelial
Chordoid
Papillary
Fibrous ( fibroblastic)
Clear cell
Rhabdoid
Transitional (mixed)
Atypical
Anaplastic
Psammomatous
Angiomatous
Microcystic
Secretory
Lymphoplasmacyte
Metaplastic

13. Distribution by histopathological grade

14. Distribution by histopathological type in benign tumors

15. Distribution by histopathological type in atypical and malignant tumors

16. EDEMA HYPEROSTOSIS EXTRACRANIAL TUMOR EXTENSION
Imaging findings observed
EDEMA
HYPEROSTOSIS
EXTRACRANIAL TUMOR EXTENSION
HETEROGENEOUS TUMOR ENHANCEMENT
CAPSULAR ENHACEMENT
INDISTINCT TUMOR BORDERS

17. Imaging findings in benign and malignant meningiomas

18. Axial T1WI MR with contrast shows heterogeneous enhancement, with small areas of hyposignal included in the lesion
Axial T2WI MR shows: mass attached by a broad base to the falx (white arrow), with associated perifocal edema (white opened arrow

19. Coronal T1WI +C MR shows a mass localized on the bases of the anterior fossa, which presents:
- capsular enhancement
- heterogeneous signal, with areas of -hyposignal included characteristic for calcification
- Hyperostosis of the sphenoidal bone
Axial NECT with bone window shows a heterogeneous mass adjacent to the left inner parietal table of the skull, with extended calcifications included (white arrow), and associated marked hyperostosis of the skull (open arrow)

20. Conclusions

21. 1
Indistinct borders , heterogeneous tumor enhancement and hyperostosis – significantly associated with advanced histopathological grade
Imaging features may lead to noninvasive differentiation between benign and atypical or malignant tumors
Imaging evaluation can provide useful information in preoperative diagnosis and therapeutic strategy 2 3

22. Limitations
Directions
&
for future research

23. Retrospective Prospective Dust Dark Mold TIME Subjective
Improved follow up
Better use of time
Objective

24. Bibliography
1. Abbott K.H., Courville C.B. – Historical notes of the meningiomas, I.A. study of hyperostosis in prehistoric skulls, Bull Los Angeles Neurol Soc., 1939, I4:
2.Cushing H., Eisenhardt L.- Meningiomas: Their Classification, Regional Behaviour, Life 2. History ansd Surgical End Results, Springfield, IL: Charles C Thomas, 1938
Moodie R.L- Tumors of the head among pre-Columbian Peruvians, Ann Med Hist, 1926, 8:
3. Wang H., Lanzino G., Laws E.R.J.- Meningioma: the soul of neurosurgery:historical review, Sem Neurosurg, 2003, 14:
4. Netsky M.G.- The first account of a meningioma, Bull Hist Med, 196, 30:
Al- Rodhan N.R., Laws E.R.J.- Meningioma: a historical study of the tumor and its surgical management, 1990, 26:
5. Al- Rodhan N.R., Laws E.R.J.- Meningioma: a historical study of the tumor and its surgical management. In: Al-Meftey O., Raven press, New York, 1991:1-8
Louis A.- Mémoire sur les Tumeures Fongueuses de la dure-mère, Mem Acad R Chir, Paris, 1774, 5:1-59
6. Cushing H.- The meningiomas( dural endothelomas): their source, and favored seats of origin, Brain, 1922, 45:
7. Bondy M., Ligon BL.- Epidemiology and etiology of intracranial meningiomas: A review, J neurooncol, 1996, 29:

25. Thank you for your attention!