1. Human Chromosome Disorders

2. Karyotype—Map of Human Chromosomes Homologue

4. Chromosome disorders Sometimes meiosis goes wrong Most of the time, the pregnancy ends naturally because most chromosome disorders are lethal Extra chromosome = trisomy

5. 21 trisomy – Downs Syndrome Can you see the extra 21 st chromosome? Is this person male or female?

6. Down’s syndrome *A flattened appearance to the face *An upward slant to the eyes * Short neck, arms and legs *Intellectual disability *Extra friendly and outgoing

7. Edward’s syndrome-trisomy 18 Clenched hands Crossed legs Feet with a rounded bottom (rocker-bottom feet) Mental deficiency Small head

8. Patau syndrome Trisomy 13

9. Turner’s syndrome—the only case of missing a chromosome that can be survived Females who are XO instead of XX Stocky appearance, arms that turn out slightly at the elbow, a receding lower jaw, a short webbed neck. Other medical symptoms include: heart and/or kidney defects, high blood pressure, and infertility (inability to have children).

10. What if a karyotype showed you would have a child with a chromosomal abnormality? What would you do?