1. 1

2. 2

3. Bangalore, Dec. 2014 Patriarchal community Easy acceptance of genetic disorder or carrier status in close relatives No religious and social differences Social restrictions for youth relationship Family economic considerations Parental pressure for marriage Paranoia 3

4. Bangalore, Dec. 2014 Risk of bleeding (menorrhagia, post partum) Frequent hospital visits Grim educational and career prospect Isolation and no engagement with peers, community Impact on relationships and marriage (less desirable for marriage) Divorce husband’s remarriage Impaired self-esteem, guilt, fear, anxiety, sadness Blood born infectious diseases Financial stress 4

5. Bangalore, Dec. 2014 Mothers; impaired self-esteem, guilt, fear, anxiety, sadness, Marriage (vulnerable situation) Society in-laws pressure Future pregnancies Abortion Risk of bleeding (menorrhagia, post partum) Sisters; carrier status affects sisters lives Anxiety giving birth to unhealthy sons Stigma (less desirable for marriage) Risk of bleeding (menorrhagia) 5

6. Kish, Jan., 2014

7. Bangalore, Dec. 2014 Total 240 7

8. Population Growth of Female Bleeders Bangalore, Dec. 2014 8

9. Paris, July, 2012 Carriers need to be followed up at the hemophilia treatment centre and should be checked for their factor levels Psychosocial care for carriers of hemophilia should be provided Gynecologists and obstetricians should be guided Genetic counseling services should be established and basic information about inheritance should be provided 9

10. Melbourne, May, 2014 10 Mahatma Gandhi The loss of health is loss of all happiness. “It is health which is real wealth, and not pieces of gold and silver”.