1. The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis)Teng on human epidermoid KB cells 任課老師 : 詹于誼 學 生 : 唐若廷 & 陳玉貞 日 期 : 2008 06 10 Journal of Ethnopharmacology 105 (2006) 280–285

2. Introduction 桑黃（ Phellinus linteus ）為一種寄生於闊葉樹上 的刺革菌科菇類，因其生長緩慢，取得不易，加 上難以人工栽培，故有「夢幻菇蕈」之稱。

3. Classification of Phellinus linteus

4. Phellinus linteus(PL) 的成分介紹 Polysaccharides Triterpenoids phenolics Meshimakobnol Proteins Mineral

5. Pharmacological study of Phellinus linteus  Phellinus linteus (PL), a traditional medicinal mushroom, for the treatment of various diseases.  gastroenteric disorder  peptic ulcers  lymphatic disease  various cancers

6.  Recent studies have shown that PL has  anti-inflammatory  antimutagenicity  antibacterial effects  stimulates immunity  inhibits tumor growth and metastasis

7. Hispolon 分子結構 : 化學名 : 6-(3,4-dihydroxy-phenyl)-4-hydroxy-hexa- 3,5-dien-2-one 分子式 : C 12 H 12 O 4 分子量 : 220.22  Hispolon,a yellow pigment was first found in Inonotus hispidus in 1996

8. Hispolon, an active polyphenol compound, is known to possess potent induces apoptosis in cancer cells.

9. That hispolon could induce human epidermoid KB cell apoptosis accompanied by the collapse of mitochondrial membrane potential. Hispolon induces apoptosis in cancer cells : treatment of oral cancer

10. the efficacy of hispolon in human gastric cancer cells and explored the cell death mechanism. Hispolon induced ROS-mediated apoptosis in gastric cancer cells. Free Radical Biology & Medicine 45 (2008) 60–72 treatment of gastric cancer

11. antiviral antiproliferative immunomodulatory activity antioxidant activity  Other studies also showed that hispolon has

12. antiviral of Hispolon : hispolon showed considerable antiviral activity against influenza viruses type A and B. Received 8 November 2002; accepted 8 April 2003

13. Hispolon also suppress mitogen induced proliferation of spleen lymphocytes of mice. antiproliferative of Hispolon : Pharmazie. 1996 Sep;51(9):667-70

14. Isolation and purification of hispolon 1.5kg fruiting body of PL 95%EtOH removal of the EtOH under reduced pressure at 40 ◦ C, a dark yellow residue (64.5 g) silica gel column chromatography eight major fractions fraction 3 (3.37 g) silica gel column chromatography reversed-phase HPLC red crystals (65 mg) hispolon Etopside