1. Outline Learning Objectives Analyze the cell cycle and its relationship to cancer Evaluate the role of life style and risk factors that might contribute to cancer Scientific Reasoning Evaluate popular literature as it relates to Formative Assessments Think Pair Share Activities/Clickers to identify cellular changes in cancer cells Summative Assessment Evaluate a claim on the ability of ellagic acid in raspberries to prevent cancer

2. Figure 5.12 Biology: Science for Life 2/e ©2007 Pearson Prentice Hall, Inc. G1G1 G2G2 M S Cell cycle G 1 checkpoint G 2 checkpoint Metaphase checkpoint Are all the chromosomes attached to microtubules? Are sufficient nutrients available? Is the cell large enough? Are growth factors present? Is cell division necessary? Is the cell large enough? Was DNA replicated correctly? Tumor suppressors- stop Growth factors- go

3. Cell Cycle Control and Mutation - Many Mutations Are Required for Cancer to Develop  Progression from benign tumor to cancer requires many mutations.  Immortalization  Loss of contact inhibition  Angiogenesis  Loss of anchorage dependence

5. Where is the Tumor? A C B D

6. Is the Normal Colon on the Right or the Left? B A

7. Think Pair Share What do these pictures have in common?

9. Think Pair Share What is different between these two panels?

10. What specific areas of the cell cycle appear to be affected?

13. Class Data 1.Does Family History play a pivotal role in the development of cancer? Explain 2.What were the top three cancers? In your opinion why were these cancers the most popular? 3.What was the most common possible risk factor? 4.Cancer is often described as the disease of the aged. This statement may be inconsistent with your class data. What explanation can you offer in support of this statement?