1. 7/23/99 NIH/NIGMS Support of Structural Biology NIH individual research grants with crystallography projects (FY 98) –primary: 225 grants, $51M total costs –secondary: 400 grants, $96M total costs –NIGMS is 50% of each NIH program projects and NCRR research resources: approx. $30M for protein crystallography

2. 7/23/99 NIGMS Initiative for Synchrotron Beamlines Beamline upgrades for benefit of general users Reports on increasing demand for user access and beamline needs Estimate of doubling of capacity for crystallographic experiments from staff increases and equipment upgrades Letter to synchrotron facility directors inviting informal proposals NIGMS synchrotron advisory group FY99 funding of $7M from NIGMS

3. 7/23/99 Synchrotron Beamline Upgrades Supported by NIGMS upgrades to 4 beamlines CCD detectors computer wet lab four beamline scientists/technicians one staff for new review/scheduling process $1,770K equipment $705K annual – staff Stanford Synchrotron Research Laboratory

4. 7/23/99 Synchrotron Beamline Upgrades Supported by NIGMS reconstruction of bending magnet beamline ncluding beamline optics, monochrometer, detector, crystallography station four beamline scientists/technicians $2,372K equipment/construction $670K annual – staff National Synchrotron Light Source

5. 7/23/99 Synchrotron Beamline Upgrades Supported by NIGMS upgrades to three beamlines beamline optics and cooling equipment, monochrometer, automation/ monitors, computer two beamline scientists $1,238K equipment $340K annual – staff Cornell High Energy Synchrotron Source

6. 7/23/99 Synchrotron Beamline Upgrades Supported by NIGMS upgrade to the focusing optics for one beamline and a detector low temperature system and computer for a new beamline four beamline scientists/ technicians $963K equipment $259K annual – staff Advanced Light Source

7. 7/23/99 Synchrotron Beamline Construction Supported by NIGMS construction of a new crystallographic beamline two beamline scientists cofunded with the NSF, Louisiana State University, and a consortium of PIs in the southern U.S. $1,260K construction/equipment (NIGMS & NSF) $206K annual – staff (NIGMS & NSF) Center for Advanced Microstructures and Devices

8. 7/23/99 Synchrotron Beamline Construction Supported by NIGMS development of a new crystallographic sector of two crystallographic beamlines partnership with the NCI two years of NIGMS/NCI funding for construction. $18M construction/equipment (NIGMS & NCI) Advanced Photon Source