1. After Mendel Ch. 8 – 3 (con’t) Beyond Dominant And Recessive Alleles Dominant/recessive inheritance is the simplest type of gene interaction What causes dominance? The dominant allele codes for a polypeptide that WORKS! The recessive allele doesn’t

2. Pedigree – a diagram that shows the occurance of a genetic trait in several generations of a family

5. Autosomal or Sex-linked Autosomes – any chromosome that is NOT a sex chromosome In humans, 22 pairs of autosomes (44 chromosomes) Sex chromosomes – chromosome pair that is different in males and females X chromosome - sex chromosome; in humans and many other organisms females have 2 X’s and males have only 1 Y chromosome - male sex chromosome (in humans and many other organisms) ex. In humans XX = female XY = male

6. Sex Determination XX x XY Genes on the Sex Chromosomes In addition to determining the sex of an individual, sex chromosomes carry genes that affect other traits (not related to sex) Sex-linked - a trait that is determined by a gene found on one of the sex chromosomes, such as the X (and Y) chromosomes in humans (most are X-linked)

7. Thomas Hunt Morgan (early 1900’s) discovered the 1st sex-linked trait in Drosophila Studied Drosophila melanogaster, fruit fly Found: that Mendel’s principles applied to other organisms

8. - Small and easily raised and kept -Has obvious characteristics and easy to distinguish male and female -Has a short life span -Produces a large number of offspring -Has only 4 pairs of chromosomes, which are very large The Characteristics of Drosophila

9. Morgan’s Research Bred and looked at many fruit flies looking for an interesting trait Found a white-eyed male Crossed: P gen: normal red-eyed female x white-eyed male F1 gen:all offspring red-eyed (allowed to interbreed) F2 gen:got expected 3 red-eyed : 1 white-eyed BUT all white-eyed were MALES

10. P gen F1 genAll F1 offspring are red-eyed

11. Morgan hypothesized that gene for eye color in Drosophila was sex-linked and he performed a test cross. Test cross 1 Crossed red-eyed female (F1) x white-eyed male Test cross 2 Crossed red-eyed male (F1) x white-eyed female

12. Morgan concluded: that the gene for eye color (in Drosophila) is carried on the X chromosome and there is NO corresponding allele on the Y chromosome (Y is smaller so it is reasonable to assume that the Y is missing genes) carrier – heterozygous (female) for a (sex-linked) trait Sex-linked (X-linked) traits in humans red-green colorblindness hemophilia Duchenne muscular dystrophy ALD (adrenoleukodystrophy)

13. Chapter 8 - 4 Complex Patterns of Heredity (pg. 177) Since Mendel, scientists have discovered many genes that do NOT follow the simple patterns of inheritance described by Mendel (he described dominant/recessive inheritance). Many time genes exhibit more complex patterns of inheritance (or gene interaction)

14. Traits Influenced by Several Genes Polygenic Trait - trait controlled by 2 or more gene pairs; a characteristic of an organism that is determined by many genes Ex. All of these traits have degrees of intermediate conditions between one extreme and the other

15. Example: Trait controlled by 3 gene pairs

18. Characterized by: F1 generation with phenotype intermediate to parent phenotypes F2 generation with a phenotype ratio of 1: 2: 1 (instead of Mendel’s 3:1 Incomplete Dominance - Condition in which a trait in an offspring is intermediate between phenotype of the 2 parents because the dominant allele is unable to express itself fully; “blending” inheritance

19. Incomplete Dominance

20. Traits with Two Forms Displayed at the Same Time Codominance - Condition in which BOTH alleles of a gene are fully expressed Both alleles are active (or expressed) Example: coat color in horses (or cattle) Roan = mixture of red and white hairs

21. Codominance P gen Red coated x white coated C R C R x C W C W F1 gen All roan coated All C R C W F2 gen 1 Red : 2 Roan: 1 White 1 C R C R : 2C R C W ; 1C W C W

22. P generation F1 Cross F2 Offspring

23. Traits Controlled by Genes with Three or More Alleles Multiple Alleles – 3 or more alleles for a genetic trait Individual still has only 2 alleles (1 from each parent) Ex. Human ABO blood groups 3 Possible Alleles: I A, I B, i Gene codes for an antigen (protein) on red blood cells

24. 4 Phenotypes6 Genotypes Type AI A I A or I A i Type BI B I B or I B i Type ABIAIBIAIB Type Oii

25. Gene Interaction A and B are codominant A and B are dominant over O O is recessive

26. Human Blood Typing

28. Transfusion possibilities Type (antigen) Antibodies in plasma Can Receive From Can Donate To AAnti-B antibodies A, OA, AB BAnti-A antibodies B, OB, AB ABNeitherA, B, AB, OAB OAnti-A antibodies Anti-B antibodies OA, B, AB, O

29. Blood Typing Anti-A antibodies Anti-B antibodies

30. Multiple Alleles – Coat Color in Rabbits Full Color C allele CC or Cc chd or Cc h or Cc Chinchilla (dark) c chd c chd or c chd c h or c chd c Chinchilla (light) or Sable C chl c chl or c chl c h or c chl c Himalayan c h c h or c h c Albino cc

31. Traits Influenced by the Environment Hydrangea flower color is determined by soil pH Acidic soil results in blue flowers Neutral to basic soil results in pink flowers An individual’s phenotype may depend on conditions in the environment - some genes are influenced by environmental factors, some are NOT Acidic soil Basic soil

32. Arctic Fox - fur color affected by temperature In summer with warm temperatures enzymes are produced that make pigment that darkens fur In winter With cold temperatures enzymes needed for pigment production do NOT function resulting in white fur

33. Fur color in Siamese cats Influenced by temperature Dark fur produced at body locations that are cooler than normal body temperature (extremities - nose, ears, paws and tail)

34. Epistasis – a phenomenon in which one gene alters the expression of another gene that is independently inherited B = Black b = brown C = controls whether any pigment is deposited in the hair c = no pigment in hair All offspring with cc are white regardless of the black/brown gene

35. Siamese cats. One gene controls the color of the pigment, and black hair (B) is dominant to brown hair (b). The other gene controls the dilution of the pigment in the hairs, with dense pigment (D) being dominant to dilute pigment (d). Geno types Phenotype F 2 ratio BBDD BBDd BbDD BbDd “seal” (black dense)9 BBdd, Bbdd “blue” (black dilute)3 bbDD, bbDd “chocolate” (brown dense) 3 bbdd“lilac” (brown dilute)1

37. BB = black Lab, no chocolate gene Bb = black Lab, bb = chocolate Lab, no black gene Yellow is produced by the presence of a recessive epistatic gene which has the effect of blotting out the expression of the black or chocolate genes. If "E" = the dominant form of for the epistatic gene, and "e" = the recessive form, then there are three possibilities: EE = no yellow gene Ee = yellow carrier but apears either black or chocolate ee = yellow Lab

38. = or or or = or or = or