1. Robbins’ Basic Pathology 2-20 7 th Ed. Histology of Chronic Inflammation

2. Maturation of Monocytes into Macrophages Robbins’ Basic Pathology 2-21

3. Adapted from Robbins’ Basic Pathology 2-22 Macrophage/Lymphocyte Stimulation

4. Adapted from Robbins’ Basic Pathology 3-16 7 th Ed Responses to Injury

5. Phases of Wound Healing Robbins’ Basic Pathology 3-14

6. Cellular Adaptation to Injury Atrophy Hypertrophy Hyperplasia Metaplasia

7. Robbins’ Basic Pathology 1-4 Atrophy

8. Robbins’ Basic Pathology 1-3 Hypertrophy (increase in cell size) Uterus during pregnancy

9. Hyperplasia (increase in cell number) Thyroid Adenoma Robbins’ Pathologic Basis for Disease 8-6

10. Robbins’ Basic Pathology 1-19 7 th Ed. Irreversible –plasma membrane damage –Damaged mitochondria –damage lysosomes Reversible vs. Irreversible Cell Injury Reversible –Loss of ATP= cell swelling –glycolysis=lactic acid= decreased pH –decreased protein production

11. Robbins’ Basic Pathology 1-6 7 th Ed. Transition from Reversible to Irreversible

12. Robbins’ Basic Pathology 1-6 Necrosis vs. Apoptosis Chromatin clumping Organelle swelling Membrane Damage Necrosis

13. Robbins’ Basic Pathology 1-12 Necrosis vs. Apoptosis Chromatin condensation and fragmentation. Cytoplasmic budding. Phagocytosis of extruded apoptotic bodies. Apoptosis

14. Robbins’ Basic Pathology 1-23 Apoptosis 1. Stimulus of apoptosis. (Death ligands, lack of growth factors or hormones, Injury). 2. Regulatory cytoplasmic proteins. (BCL-2 family) (Some promote some inhibit apoptosis) 3. Execution caspases. (Activate endonucleases and proteinases). 4. Formation of Apoptotic Bodies. (contain organelles and cytosolic components).

15. Adapted from Robbins’ Basic Pathology 1-25 7 th Ed. A N

16. Next Time Introduction to the immune system Readings: Abbas & Lichtman, Chapter 1

17. Objectives 1.Describe the pathophysiology of acute inflammation. 1.Chronology, vascular changes, cellular events, histology, resolution. 2.Differences from chronic inflammation 2.Describe the response and the cellular adaptations to injury. 1.Phases of wound healing 2.Atrophy, Hypertrophy, Hyperplasia, Metaplasia 3.Describe the differences between reversible and irreversible injury. 4.Describe the differences between apoptosis and necrosis.