1. Chapter 14 Hallucinogenic Drugs

2. Mescaline Peyote cactus

3. Psilocybin Psilocybe mushrooms psilocybin  psilocin

4. LSD

5. Pharmacology of Hallucinogenic Drugs

6. LSD Trip (psychological effects) 1.Onset 2.Plateau 3.Peak 4.Come-down Pharmacology of Hallucinogenic Drugs

7. Physiological effects Activate sympathetic nervous system –Dilated pupils –Heart rate increase –Blood pressure increase –Body temperature increase Dizziness Nausea and vomiting Pharmacology of Hallucinogenic Drugs

8. Most hallucinogens are 5-HT receptor agonists If you use a 5-HT receptor antagonists together with a hallunicongen, illusions and hallucinations disappear Pharmacology of Hallucinogenic Drugs

9. Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue

11. Problems with hallucinogenic drugs “Bad Trip” Flashbacks Psychotic breakdown Pharmacology of Hallucinogenic Drugs http://www.antidrug.health.am/img/haluc.jpg

12. PCP Dissociative Anesthetics

13. Ketamine crystals Dissociative Anesthetics

15. PCP Self-administration of PCP into the nucleus accumbens shell by rats

16. Ketamine Ketamine administration produces a dose-dependent increase in psychotic- like symptoms