1. 1 18.01.2011 Use and production of radionuclide platinum-195m for nuclear medicine Technology and Equipment Development for Photonuclear Production of Medical Radionuclides e-e-  RF linac ConverterAu-target Energy 30-60 MeV Beam power 10-20 kW !!!! Water 197 Au(g,np) 195m Pt

2. 2 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides NSC KIPT 1991-2011 KUT-30 W up to 35 MeV P up to 20 kW

3. 3 18.01.2011 NSC KIPT, Ukraine Technology and Equipment Development for Photonuclear Production of Medical Radionuclides

4. 4 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Converter Target capsule Electron beam

5. 5 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides The 195m Pt obtain in reaction 197 Au( ,np) 195m Pt (T 1/2 =4.02 days). The 195m Pt decay is accompanied by  -radiation of nuclear transactions, X- rays and electrons of internal conversion. The Auger-MXY electrons have energy 2.417 keV and its abundance is 3.22 per 195m Pt decay. The LET of this Auger electrons are 9.5 keV/  m and the range 0.25  m. Therefore for incorporate cisplatin molecule the range of Auger electrons will be within the size of cell nucleus. The biological efficiency of electrons will be 100-300 times higher than in the case of malignant tumor irradiation by the external irradiation with the use of isotopes having significantly higher energies of particles (  -radiation, electrons). Сisplatin penetrate into cell nucleus during treatment of cancerogenic illnesses.

6. 6 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides The dry precipitate H 2 [PtCl 6 ]  6 H 2 O was subjected to treatment with boiling water and was evaporated again on the water bath. Then the fresh 25% solution of potassium chloride was added to the tenfold-water solution of platinum hydrochloric acid up to the complete precipitation. H 2 [PtCl 6 ] + 2KCl = H 2 [PtCl 6 ] + 2HCl The yellow crystalline precipitation was obtained. After cooling the precipitate was washed during 1.5-2 hours with the diluted potassium chloride solution and alcohol. The obtained precipitate in the 6-7 fold quantity of water was slowly heated to boiling. In the process, as the quantity was small, water was added to the required volume. A 5% excess of lemon salt (0.39 g K 2 C 2 O 4  Н 2 О на 1 g K 2 [PtCl 6 ]) was added to the boiling mixture. H 2 [PtCl 6 ] + K 2 C 2 O 4 = K 2 [PtCl 4 ] + 2KCl + 2CO 2 After boiling during 1 hour the red-crimson precipitate was formed. The obtained solution of potassium chloroplatinite K 2 [PtCl 4 ] with addition of a necessary quantity of 20% solution of ammonium acetate (CH 3 COONH 4 ) and potassium chloride was boiled during 1.5 hours with water replenishment. After cooling the precipitate of Pejrone salt of canary color was precipitated. K 2 [PtCl 4 ] + 2CH 3 COONH 4 = (NH 3 Cl) 2 Pt + 2CH 3 COOK + 2HCl Synthesis of radioactive cisplatin

7. 7 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Effect of high- active cisplatin on the Ehrlich cells, 120 min, 0.017 picograms The effect of initial and radioactive cisplatin with a high specific activity (~1Ci/mg) on the suspension of Ehrlich adenocarcinoma cells was investigated.

8. 8 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Action of initial and radioactive cisplatin on the Ehrlich adenocarcinoma cell viability NSC KIPT develops a photonuclear method of production of medical isotopes ( 99m Tc, 67 Cu, 103 Pd etc.). After installation of hot cell we can deliver 195m Pt isotope. Also we can carry out joint researches for further use radioactive cisplatin in nuclear medicine.

9. 9 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides White outbred mice with Ehrlich solid carcinoma under testing the action of initial and radioactive cisplatin We investigated influence of radioactive cisplatin on a tumour of mice. Percentage of the solid Ehrlich tumor growth inhibition after injection of initial and radioactive cisplatin was 35% and 65% respectively.

10. 10 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides ZnO nanoparticles are used as the selective cytotoxic agent for destruction of cancer cells. We investigate cytotoxic effect of synergetic influence of ZnO nanoparticles and radioactive Zn Auger electrons upon normal and malignant cells. Cytotoxicity patterns of various metal oxides

11. 11 18.01.2011 Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Thank you for attention