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Integrating Cells into Tissues
Sho Momota
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CAM(Cell-adhesion molecules)
ECM(Extra cellular matrix)
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ECM Proteoglycans Collagen fibers Multiadhesive matrix proteins
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CAM Cadherins Ig (immunoglobulin) super family Selectins Mucins
integrins
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Cadherins Ca N-teminus Extra cellular region cell membrane
50-60% of the sequence is identical among different cadherins. C-teminus Cytoplasm
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Types of cadherin More than 40 different cadherins are known
E-cadherin : Preimplantation embryos, non-neural epethelial tissue P-cadherin : Trophblast N-cadherin : nervous system, lens, cardiac and skeletal muscle
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Character of cadherin Homophilic (like bind like)
E-cadherins bind to E-cadherins P-cadherins bind to P-cadherins E-cadherins usually not bind to P-cadherins
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N-CAMs Group of Ca-independent cell-adhesion proteins
Ig super family of CAMs Primarily Homophilic interaction Encoded by a single gene.
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Selectin Extravasation of leukocytes
Blood Sialyl Lewis-x antigen Extravasation of leukocytes require the successive formation and breakage of cell-cell contacts between leukocytes in the blood and endothelial cells lining the vessels Sugar binding lectin domain P-selectin Endothelial cell
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Integrin Heterodimers of and subunits
Exhibit relatively low affinities for the ligands
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Accelerates a formation of clot
IIb3 integrin platelet Accelerates a formation of clot Collagen or thrombin Conformational change of IIb3 integrin Fibrinogen platelet Activated platelet
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Deadhesion factors Promote cell migration and can remodel the cell surface Disintegrins ECM RGD sequence
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De-adhesion factors CELL CAM ECM Disintegrins
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Question?
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